J
James D. Lauderdale
Researcher at University of Georgia
Publications - 68
Citations - 1541
James D. Lauderdale is an academic researcher from University of Georgia. The author has contributed to research in topics: PAX6 & Aniridia. The author has an hindex of 20, co-authored 59 publications receiving 1260 citations. Previous affiliations of James D. Lauderdale include University of Michigan & Purdue University.
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Directed differentiation of human pluripotent cells to neural crest stem cells
Laura Menendez,Michael Kulik,Austin T Page,Sarah S. Park,James D. Lauderdale,Michael L. Cunningham,Michael L. Cunningham,Stephen Dalton +7 more
TL;DR: After completion of this protocol, NCSCs can be used for numerous applications, including the generation of sufficient cell numbers to perform drug screens, for the development of cell therapeutics on an industrial scale and to provide a robust model for human disease.
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3′ deletions cause aniridia by preventing PAX6 gene expression
TL;DR: Using human x mouse retinoblastoma somatic cell hybrids, it is shown that PAX6 is transcribed only from the normal allele but not from the deleted chromosome 11 homolog, suggesting that remote 3' regulatory elements are required for initiation of PAX6 expression.
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Axon tracts correlate with netrin-1a expression in the zebrafish embryo.
TL;DR: Analysis of netrin-1a within the relatively simple and well-characterized nervous system of zebrafish embryos suggests that netrins act on many growth cones and influence their behavior in a variety of ways.
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Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb.
Jiha Kim,James D. Lauderdale +1 more
TL;DR: Results demonstrate a role for Pax6DeltaPD in eye development, which appears to be different than that ascribed to either canonical Pax6 or Pax6(5a), and identify, for the first time in mammals, an isoform of the Pax6 protein lacking the paired domain.
Journal ArticleDOI
PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF.
Shaul Raviv,Kapil Bharti,Sigal Rencus-Lazar,Yamit Cohen-Tayar,Rachel Ben-Haroush Schyr,Naveh Evantal,Eran Meshorer,Alona Zilberberg,Maria Idelson,Benjamin Reubinoff,Rhonda Grebe,Rina Rosin-Arbesfeld,James D. Lauderdale,Gerard A. Lutty,Heinz Arnheiter,Ruth Ashery-Padan +15 more
TL;DR: This study exemplifies how one kernel gene pivotal in organ formation accomplishes a lineage-specific role during terminal differentiation of a single lineage.