James D. Madden

TL;DR: The demonstration of markedly deficient dihydrotestosterone formation in slices of perineal skin, epididymis and phallus, is compatible with the fact that dihydotestosterone is the fetal hormone responsible for male differentiation of the external genitalia, iscompatible with the idea that androgen resistance in this syndrome is different from that in other androgen-resistant states.

TL;DR: The rise in plasma ACTH concentrations, asregnancy advances, is suggestive of the possibility that a source of ACTH exists that is not subject to negative feedback control, that the clearance of free cortisol increases as pregnancy advances, or that there is an alteration in the metabolism of the ACTH precursor protein produced by the pituitary and/or placenta.

TL;DR: It is believed that congenital absence of the vagina associated with a variable abnormality of the uterus may represent the variable manifestation of a single underlying genetic defect that can be expressed alone or in any combination of vertebral, renal, and genital abnormalities.

TL;DR: The purpose of this study was to quantify the various sources of estrone (E1) and 17 beta-estradiol (E2) production in normal men and in women with testicular feminization.

TL;DR: The fact that men with testicular tumors have a high incidence of human chorionic gonadotropin-beta secretion provides the physician with a powerful new tool for examining the various aspects of tumor activity and shows the feasibility for prospective screening of patients with a wide variety of neoplasms of differing histologic types.