James Egan

TL;DR: Genetic amniocentesis should be considered in women of any age when second-trimester ultrasonography reveals the presence of one or more of the following: fetal structural malformations, short femur (determined by biparietal diameter-to-femur length ratio), combination of short Femur and humerus, abnormal nuchal fold thickening, echogenic bowel, or short ear length.

TL;DR: Pregnancies complicated by preterm premature rupture of membranes after genetic amniocentesis result in significantly better perinatal outcomes compared with pregnancies complicated by spontaneous pre term premature ruptures of membranes at a similar gestational age.

TL;DR: According to these tables, a patient at 33 years of age with a twin gestation has a risk of Down syndrome in at least one of her twins equivalent to that of a 35-year-old with a singleton.

TL;DR: A maternal age cutoff of 35 years in the 1990s resulted in high false-positive rates and was less efficacious based on likelihood ratio and positive predictive value, andSerum testing of all pregnant women would reduce the number of amniocenteses and decrease procedure-related losses.

TL;DR: The objective of this study is to assess the opinions of Fellows of the American College of Obstetricians and Gynecologists on expanded carrier testing and noninvasive prenatal testing.