Institution
University of Connecticut Health Center
Healthcare•Farmington, Connecticut, United States•
About: University of Connecticut Health Center is a healthcare organization based out in Farmington, Connecticut, United States. It is known for research contribution in the topics: Population & Gene. The organization has 9336 authors who have published 16472 publications receiving 750889 citations. The organization is also known as: UConn Health Center & UConn Medical Center.
Topics: Population, Gene, Osteoblast, Cancer, Receptor
Papers published on a yearly basis
Papers
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TL;DR: The AUDIT provides a simple method of early detection of hazardous and harmful alcohol use in primary health care settings and is the first instrument of its type to be derived on the basis of a cross-national study.
Abstract: The Alcohol Use Disorders Identification Test (AUDIT) has been developed from a six-country WHO collaborative project as a screening instrument for hazardous and harmful alcohol consumption. It is a 10-item questionnaire which covers the domains of alcohol consumption, drinking behaviour, and alcohol-related problems. Questions were selected from a 150-item assessment schedule (which was administered to 1888 persons attending representative primary health care facilities) on the basis of their representativeness for these conceptual domains and their perceived usefulness for intervention. Responses to each question are scored from 0 to 4, giving a maximum possible score of 40. Among those diagnosed as having hazardous or harmful alcohol use, 92% had an AUDIT score of 8 or more, and 94% of those with non-hazardous consumption had a score of less than 8. AUDIT provides a simple method of early detection of hazardous and harmful alcohol use in primary health care settings and is the first instrument of its type to be derived on the basis of a cross-national study.
11,042 citations
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Columbia University1, University of Pittsburgh2, Florey Institute of Neuroscience and Mental Health3, Stanford University4, German Cancer Research Center5, Ludwig Maximilian University of Munich6, Yale University7, Memorial Sloan Kettering Cancer Center8, Dresden University of Technology9, Wistar Institute10, National University of Mar del Plata11, University of Texas Health Science Center at San Antonio12, Guangzhou Medical University13, University of Connecticut Health Center14, Nagoya University15, New York University16, University of Arizona17
TL;DR: The mechanisms underlying ferroptosis are reviewed, connections to other areas of biology and medicine are highlighted, and tools and guidelines for studying this emerging form of regulated cell death are recommended.
3,356 citations
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California Institute of Technology1, University of Hertfordshire2, University of California, Berkeley3, Jet Propulsion Laboratory4, University of Cambridge5, Centre national de la recherche scientifique6, University of Auckland7, GlaxoSmithKline8, Max Planck Society9, Stellenbosch University10, University of Connecticut Health Center11, Virginia Bioinformatics Institute12, University of California, Irvine13, Keio University14, Princeton University15
TL;DR: This work summarizes the Systems Biology Markup Language (SBML) Level 1, a free, open, XML-based format for representing biochemical reaction networks, a software-independent language for describing models common to research in many areas of computational biology.
Abstract: Motivation: Molecular biotechnology now makes it possible to build elaborate systems models, but the systems biology community needs information standards if models are to be shared, evaluated and developed cooperatively. Results: We summarize the Systems Biology Markup Language (SBML) Level 1, a free, open, XML-based format for representing biochemical reaction networks. SBML is a software-independent language for describing models common to research in many areas of computational biology, including cell signaling pathways, metabolic pathways, gene regulation, and others. ∗ To whom correspondence should be addressed. Availability: The specification of SBML Level 1 is freely available from http://www.sbml.org/.
3,205 citations
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TL;DR: In response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells, pointing to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.
Abstract: Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector levels of lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.
1,882 citations
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TL;DR: The molecular laboratory model of spore resistance mechanisms is summarized and attempts to use the model as a basis for exploration of the resistance of spores to environmental extremes both on Earth and during postulated interplanetary transfer through space as a result of natural impact processes.
Abstract: Endospores of Bacillus spp., especially Bacillus subtilis, have served as experimental models for exploring the molecular mechanisms underlying the incredible longevity of spores and their resistance to environmental insults. In this review we summarize the molecular laboratory model of spore resistance mechanisms and attempt to use the model as a basis for exploration of the resistance of spores to environmental extremes both on Earth and during postulated interplanetary transfer through space as a result of natural impact processes.
1,852 citations
Authors
Showing all 9386 results
Name | H-index | Papers | Citations |
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John R. Yates | 177 | 1036 | 129029 |
Christopher T. Walsh | 139 | 819 | 74314 |
Jun Lu | 135 | 1526 | 99767 |
Peter A. Ward | 125 | 674 | 52878 |
William J. Kraemer | 123 | 755 | 54774 |
Thomas D. Pollard | 122 | 446 | 56230 |
George M. Weinstock | 122 | 482 | 144274 |
John E. Ware | 121 | 327 | 134031 |
Kyriacos C. Nicolaou | 120 | 1350 | 68945 |
Sarah Spiegel | 120 | 405 | 48937 |
Ronald D. Vale | 117 | 342 | 49020 |
Harold F. Dvorak | 117 | 351 | 59592 |
Michael P. Sheetz | 116 | 368 | 48917 |
John P. Bilezikian | 116 | 612 | 48633 |
Gerhard Wagner | 116 | 589 | 50309 |