J
James F. Hainfeld
Researcher at Brookhaven National Laboratory
Publications - 157
Citations - 11245
James F. Hainfeld is an academic researcher from Brookhaven National Laboratory. The author has contributed to research in topics: Colloidal gold & Scanning transmission electron microscopy. The author has an hindex of 45, co-authored 154 publications receiving 10557 citations. Previous affiliations of James F. Hainfeld include Yale University & Stony Brook University.
Papers
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The use of gold nanoparticles to enhance radiotherapy in mice.
TL;DR: This novel use of small gold nanoparticles permitted achievement of the high metal content in tumours necessary for significant high-Z radioenhancement in mice bearing subcutaneous EMT-6 mammary carcinomas.
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Gold nanoparticles: a new X-ray contrast agent
TL;DR: Gold nanoparticles can be used as X-ray contrast agents with properties that overcome some significant limitations of iodine-based agents, and this report is the first demonstration that gold nanoparticles may overcome these limitations.
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"Plugging into Enzymes": Nanowiring of Redox Enzymes by a Gold Nanoparticle
TL;DR: The reconstitution of an apo-flavoenzyme on a 1.4-nanometer gold nanocrystal functionalized with the cofactor flavin adenine dinucleotide and integrated into a conductive film yields a bioelectrocatalytic system with exceptional electrical contact with the electrode support.
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Radiotherapy enhancement with gold nanoparticles
TL;DR: Calculations indicate that this dose enhancement can be significant, even 200% or greater, and the physical and biological parameters affecting this enhancement are discussed.
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Gold nanoparticle imaging and radiotherapy of brain tumors in mice
James F. Hainfeld,Henry M. Smilowitz,Michael O'Connor,Farrokh Avraham Dilmanian,Farrokh Avraham Dilmanian,Daniel N. Slatkin +5 more
TL;DR: Intravenously injected gold nanoparticles cross the blood-tumor barrier, but are largely blocked by the normal blood-brain barrier, enabling high-resolution computed tomography tumor imaging and holding promise to improve therapy of human brain tumors and other cancers.