J
James J. Burston
Researcher at University of Nottingham
Publications - 49
Citations - 3788
James J. Burston is an academic researcher from University of Nottingham. The author has contributed to research in topics: Osteoarthritis & Cannabinoid receptor. The author has an hindex of 24, co-authored 47 publications receiving 3302 citations. Previous affiliations of James J. Burston include Virginia Commonwealth University & University of the West of England.
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THEMED ISSUE: CANNABINOIDS RESEARCH PAPER Biochanin A, a naturally occurring inhibitor of fatty
L Thors,James J. Burston,BJ Alter,Michele K. McKinney,Ruth A. Ross,Roger G. Pertwee,Jenny L. Wiley,Christopher J. Fowler +7 more
TL;DR: Of the compounds tested, biochanin A was adjudged to be the most promising and inhibited the hydrolysis of 0.5 mM AEA by mouse, rat and human FAAH with IC50 values of 1.8, 1.4 and 2.4 mM respectively.
Journal ArticleDOI
Antagonistic Roles of Human Platelet Integrin αIIbβ3 and Chemokines in Regulating Neutrophil Activation and Fate on Arterial Thrombi Under Flow.
C. Schönichen,Samantha J. Montague,Sanne L. N. Brouns,James J. Burston,Judith M.E.M. Cosemans,Kerstin Jurk,Beate E. Kehrel,Rory R. Koenen,Fionnuala Ní Áinle,Valerie B. O'Donnell,Oliver Soehnlein,Steve P. Watson,Marijke J.E. Kuijpers,Johan W. M. Heemskerk,Magdolna Nagy +14 more
TL;DR: In this paper , a microfluidic approach was used to identify key interaction mechanisms between platelet and neutrophils using micro-fluid approaches. But the results revealed that platelet-expressed integrin αIIbβ3 prevented leukocyte adhesion, which was overcome by short-term flow disturbance provoking massive adhesion.
Journal ArticleDOI
Osteocyte phenotypes in human and monoiodoacetate-induced rat osteoarthritis
Sadaf Ashraf,James J. Burston,M. Shataheri,Daniel F. McWilliams,Victoria Chapman,Cornelia H. de Moor,David A. Walsh +6 more
TL;DR: In this article , the authors investigated the role of osteocyte dysfunction and abnormal osteocyte differentiation in osteoarthritis in subchondral bone, showing that osteocytes are central regulators of bone formation and resorption in response to loadbearing.
Posted ContentDOI
Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia
Amanda Lillywhite,Stephen G. Woodhams,Sara Vieira Gonçalves,David Watson,Li Li,James J. Burston,Peter R W Gowler,Meritxell Canals,David A. Walsh,Gareth J. Hathway,Victoria Chapman +10 more
TL;DR: In this article, a genetic model of negative affect, the Wistar-Kyoto (WKY) rat was combined with intra-articular injection of monosodium iodoacetate (MIA; 1 mg) to mimic clinical presentation, and the effects of systemic morphine (0.5-3.5 mg·kg−1) on pain behaviour and spinal nociceptive neuronal activity were compared in WKY and normo-anxiety Wistar rats 3 weeks after MIA injection.