J
James J. Burston
Researcher at University of Nottingham
Publications - 49
Citations - 3788
James J. Burston is an academic researcher from University of Nottingham. The author has contributed to research in topics: Osteoarthritis & Cannabinoid receptor. The author has an hindex of 24, co-authored 47 publications receiving 3302 citations. Previous affiliations of James J. Burston include Virginia Commonwealth University & University of the West of England.
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Journal ArticleDOI
Dynamic changes to the endocannabinoid system in models of chronic pain
Devi Rani Sagar,James J. Burston,James J. Burston,James J. Burston,Stephen G. Woodhams,Victoria Chapman,Victoria Chapman,Victoria Chapman +7 more
TL;DR: The current literature describing the impact of chronic pain states on the key components of the endocannabinoid receptor system, in terms of regionally restricted changes in receptor expression and levels of key metabolic enzymes that influence the local levels of the Endocannabinoids is reviewed.
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Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system
Bright N Okine,Leonie M Norris,Stephen G. Woodhams,James J. Burston,Annie Patel,Stephen P.H. Alexander,David A. Barrett,David A. Kendall,Andrew J. Bennett,Victoria Chapman +9 more
TL;DR: The effects of sustained pharmacological inhibition of FAAH on inflammatory pain behaviour and if pharmacological inhibiting FAAH was as effective as genetic deletion of FAAh on pain behaviour are determined.
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The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain.
Luting Xu,LN Nwosu,James J. Burston,Paul Millns,Devi Rani Sagar,Paul I. Mapp,Pongsatorn Meesawatsom,Li Li,Andrew J. Bennett,David A. Walsh,Victoria Chapman +10 more
TL;DR: It is demonstrated that anti-NGF antibody treatment attenuates OA pain behaviour despite permitting cartilage damage and synovitis, and indirect effects on subchondral bone remodelling may contribute to the analgesic effects of NGF blockade.
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Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol
Tiziana Bisogno,James J. Burston,Ravi Rai,Marco Allarà,Bijali Saha,Anu Mahadevan,Raj K. Razdan,Jenny L. Wiley,Vincenzo Di Marzo +8 more
TL;DR: Biosynthesis Inhibition: O‐5596, a new inhibitor of the biosynthesis of the endocannabinoid, 2‐arachidonoylglycerol, was synthesized and found to be potent and selective versus other proteins and enzymes of the Endocannabinoids system in vitro and active in vivo at reducing food intake in mice.
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Endocannabinoid system and pain: an introduction.
TL;DR: Critically evaluate the evidence for the role of EC in the pain pathway and the therapeutic potential of EC to produce analgesia and examine whether targeting the EC system might offer a novel target for analgesics, and also potentially disease-modifying interventions for pathophysiological pain states.