J
James L. Maller
Researcher at University of Colorado Denver
Publications - 152
Citations - 16798
James L. Maller is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Xenopus & Cyclin A. The author has an hindex of 67, co-authored 152 publications receiving 16512 citations. Previous affiliations of James L. Maller include Howard Hughes Medical Institute & Anschutz Medical Campus.
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Journal ArticleDOI
Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
TL;DR: It is demonstrated that MAP kinase is only active when both tyrosyl and threonyl residues are phosphorylated and suggested therefore that the enzyme functions in vivo to integrate signals from two distinct transduction pathways.
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Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
TL;DR: These studies suggest that a step in insulin signalling involves sequential activation by phosphorylation of at least two serine/threonine protein kinases.
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Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+.
TL;DR: It is reported here that antibodies to S. pombe p34cdc2 are able to immunoblot and immunoprecipitate the approximately equal to 32 kd component of MPF from Xenopus eggs, indicating that a Xenopus p34CDc2 homolog is present in purified MPF and suggesting that p34c2 is a component of the control mechanism initiating mitosis generally in eukaryotic cells.
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Cyclin is a component of maturation-promoting factor from Xenopus
TL;DR: Data indicate that B-type cyclin is the other component of MPF besides p34cdc2, for which exogenously added B1 and B2 cyclins are both substrates.
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Purification of maturation-promoting factor, an intracellular regulator of early mitotic events
TL;DR: The highly purified preparations described here should help to identify the mechanism of action of maturation-promoting factor and to elucidate the role of protein kinases in the induction of metaphase.