J
James M. Mullin
Researcher at Lankenau Institute for Medical Research
Publications - 101
Citations - 4539
James M. Mullin is an academic researcher from Lankenau Institute for Medical Research. The author has contributed to research in topics: Tight junction & Barrier function. The author has an hindex of 35, co-authored 98 publications receiving 4095 citations. Previous affiliations of James M. Mullin include Thomas Jefferson University & Wistar Institute.
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Journal ArticleDOI
Occludin: Structure, function and regulation
TL;DR: The structure of occludin, including its gene splice variants and protein essential components have been elucidated and phosphorylation/dephosphorylation plays a major role in regulation of occLudin and TJ.
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Increased tight junctional permeability is associated with the development of colon cancer.
Alejandro Peralta Soler,R D Miller,K. V. Laughlin,N Z Carp,David M. Klurfeld,James M. Mullin +5 more
TL;DR: Results showed that increased TJ permeability of the colon epithelium and consequently a decrease in epithelial barrier function precede the development of colon tumors.
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The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists
Sunil Thomas,Jacques Izard,Emily Walsh,Kristen A. Batich,Pakawat Chongsathidkiet,Gerard Clarke,David A. Sela,David A. Sela,Alexander J. Muller,James M. Mullin,Korin Albert,John Gilligan,Katherine M. DiGuilio,Rima Dilbarova,Walker Alexander,George C. Prendergast +15 more
TL;DR: A broad overview of the importance of the host microbiome and accumulating knowledge of how it regulates and maintains a healthy human system is provided.
Journal Article
Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability.
TL;DR: Data is presented showing that TNF affects the tight junctional region between epithelial cells, lowering the transepithelial resistance and potential difference, and increasing the flow of solute between cells and across the epithelium.
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Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets.
TL;DR: Surprisingly, activation of protein kinase C with 10(-7) M TPA resulted in a time-dependent decrease in threonine phosphorylation of occludin which correlated closely with the rapid decrease in transepithelial electrical resistance.