P
Pakawat Chongsathidkiet
Researcher at Duke University
Publications - 51
Citations - 1911
Pakawat Chongsathidkiet is an academic researcher from Duke University. The author has contributed to research in topics: Immunotherapy & Cancer. The author has an hindex of 14, co-authored 49 publications receiving 1147 citations. Previous affiliations of Pakawat Chongsathidkiet include Albert Einstein Medical Center & Chulalongkorn University.
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Journal ArticleDOI
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors.
Pakawat Chongsathidkiet,Christina Jackson,Shohei Koyama,Franziska Loebel,Xiuyu Cui,S. Harrison Farber,S. Harrison Farber,Karolina Woroniecka,Aladine A. Elsamadicy,Cosette Dechant,Hanna Kemeny,Luis Sanchez-Perez,Tooba A. Cheema,Nicholas C. Souders,James E. Herndon,Jean-Valery Coumans,Jeffrey I. Everitt,Brian V. Nahed,John H. Sampson,Michael D. Gunn,Robert L. Martuza,Glenn Dranoff,William T. Curry,Peter E. Fecci +23 more
TL;DR: It is revealed that even treatment-naïve subjects and mice with GBM can harbor AIDS-level CD4 counts, as well as contracted, T cell–deficient lymphoid organs, and sequestration of T cells in bone marrow is a tumor-adaptive mode of T cell dysfunction, whose reversal may constitute a promising immunotherapeutic adjunct.
Journal ArticleDOI
T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma
Karolina Woroniecka,Pakawat Chongsathidkiet,Kristen E. Rhodin,Hanna Kemeny,Cosette Dechant,S. Harrison Farber,Aladine A. Elsamadicy,Xiuyu Cui,Shohei Koyama,Christina Jackson,Landon J. Hansen,Tanner M. Johanns,Luis Sanchez-Perez,Vidyalakshmi Chandramohan,Yen-Rei A. Yu,Darell D. Bigner,Amber J. Giles,Patrick Healy,Glenn Dranoff,Kent J. Weinhold,Gavin P. Dunn,Peter E. Fecci +21 more
TL;DR: The poor TIL function and severe exhaustion observed in GBM highlight the need to better understand this tumor-imposed mode of T-cell dysfunction in order to formulate effective immunotherapeutic strategies targeting GBM.
Journal ArticleDOI
The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists
Sunil Thomas,Jacques Izard,Emily Walsh,Kristen A. Batich,Pakawat Chongsathidkiet,Gerard Clarke,David A. Sela,David A. Sela,Alexander J. Muller,James M. Mullin,Korin Albert,John Gilligan,Katherine M. DiGuilio,Rima Dilbarova,Walker Alexander,George C. Prendergast +15 more
TL;DR: A broad overview of the importance of the host microbiome and accumulating knowledge of how it regulates and maintains a healthy human system is provided.
Journal ArticleDOI
T-cell Dysfunction in Glioblastoma: Applying a New Framework
Karolina Woroniecka,Kristen E. Rhodin,Pakawat Chongsathidkiet,Kristin A. Keith,Peter E. Fecci +4 more
TL;DR: The various T-cell deficits elicited by GBM are divided and discussed within the context of the five relevant categories: senescence, tolerance, anergy, exhaustion, and ignorance and the emerging immunotherapeutic strategies designed to overcome them.
Journal ArticleDOI
Immune suppression in gliomas
Matthew M. Grabowski,Eric W. Sankey,Katherine Ryan,Pakawat Chongsathidkiet,Selena J. Lorrey,Daniel Wilkinson,Peter E. Fecci +6 more
TL;DR: Gliomas create a profoundly immunosuppressive environment, both locally within the tumor and systemically, which should be addressed in the effort to generate treatment options with meaningful survival benefits for this patient population.