J
James M. Ogle
Researcher at Laboratory of Molecular Biology
Publications - 5
Citations - 2739
James M. Ogle is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Transfer RNA & T arm. The author has an hindex of 5, co-authored 5 publications receiving 2627 citations.
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Journal ArticleDOI
Recognition of Cognate Transfer RNA by the 30S Ribosomal Subunit
James M. Ogle,Ditlev E. Brodersen,William M. Clemons,Michael J. Tarry,Andrew P. Carter,Venki Ramakrishnan +5 more
TL;DR: Crystal structures of the 30S ribosomal subunit in complex with messenger RNA and cognate transfer RNA in the A site, both in the presence and absence of the antibiotic paromomycin, have been solved at between 3.1 and 3.3 angstroms resolution.
Journal ArticleDOI
Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form
TL;DR: In this article, crystal structures of the 30S ribosomal subunit with codon and near-cognate tRNA anticodon stem loops bound at decoding center and compare affinities of equivalent complexes in solution were reported.
Journal ArticleDOI
Structural insights into translational fidelity
James M. Ogle,Venki Ramakrishnan +1 more
TL;DR: A large body of data on the effect of antibiotics and mutations on translational fidelity is explained, such as the mechanism of activation of GTP hydrolysis by EF-Tu, and the relationship between decoding and frameshifting.
Journal ArticleDOI
Insights into the decoding mechanism from recent ribosome structures
TL;DR: A comprehensive structural understanding of the decoding process is beginning to emerge and shows that the specific recognition of base-pairing geometry leads to a closure of the domains of the small subunit around cognate tRNA.