James Mandell

TL;DR: In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.

TL;DR: It is shown that BAI1 functions as an engulfment receptor in both the recognition and subsequent internalization of apoptotic cells, and is a phosphatidylserine recognition receptor that can directly recruit a Rac–GEF complex to mediate the uptake of apoptosis cells.

TL;DR: An increase in the activation of the MAP kinase signal transduction pathway as prostate cancer progresses to a more advanced and androgen-independent disease is suggested.

TL;DR: It may be possible to use autologous urothelium, reconfigured on a synthetic substrate, in reconstructive procedures involving the ureter, bladder and urethra, according to the results of experiments designed to determine the feasibility of using biodegradable polymers as delivery vehicles for the creation of new Urothelial structures in vivo from dissociated cells.

TL;DR: It is hypothesized that tau function could be locally regulated by phosphorylation during the period of axonogenesis, and relative levels of tau phosphorylated within developing cultured hippocampal neurons were mapped using calibrated immunofluorescence ratio measurements employingosphorylation state-dependent and state-independent antibodies.