D
David Castle
Researcher at University of Virginia
Publications - 24
Citations - 4401
David Castle is an academic researcher from University of Virginia. The author has contributed to research in topics: Exocytosis & Secretion. The author has an hindex of 16, co-authored 19 publications receiving 3622 citations. Previous affiliations of David Castle include University of Virginia Health System.
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Journal ArticleDOI
Structural and functional features of central nervous system lymphatic vessels
Antoine Louveau,Igor Smirnov,Timothy J. Keyes,Jacob D. Eccles,Sherin J. Rouhani,J. David Peske,Noël C. Derecki,David Castle,James Mandell,Kevin S. Lee,Tajie H. Harris,Jonathan Kipnis +11 more
TL;DR: In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.
Journal ArticleDOI
Sorting and storage during secretory granule biogenesis: looking backward and looking forward.
Peter Arvan,David Castle +1 more
TL;DR: This review summarizes and evaluates current information about how secretory proteins are thought to be sorted for the regulated secretory pathway and how these activities are positioned with respect to other post-Golgi sorting events that must occur in parallel.
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Relocation of the t-SNARE SNAP-23 from Lamellipodia-like Cell Surface Projections Regulates Compound Exocytosis in Mast Cells
TL;DR: It is reported that SNAP-23, a t-SNARE related to SNAP-25, relocates in response to stimulation from plasma membrane lamellipodia-like projections to granule membranes in permeabilized mast cells, and regulates compound exocytosis and linksgranule-plasma membrane and granule-granule fusions.
Journal ArticleDOI
FIP3-endosome-dependent formation of the secondary ingression mediates ESCRT-III recruitment during cytokinesis
John A. Schiel,Glenn C. Simon,Chelsey Zaharris,Julie Weisz,David Castle,Christine C. Wu,Rytis Prekeris +6 more
TL;DR: A spatiotemporal dynamics framework is provided for the coordinated efforts of actin, FIP3 endosomes and the ESCRTs to regulate cytokinesis and abscission.
Journal ArticleDOI
Protein sorting and secretion granule formation in regulated secretory cells.
Peter Arvan,David Castle +1 more
TL;DR: Observations have helped to distinguish possible mechanisms of secretory protein sorting, but there are only recent hints about the sorting processes that may be required to create the regulated secretory carrier membranes.