M
Michael R. Freeman
Researcher at Cedars-Sinai Medical Center
Publications - 412
Citations - 20766
Michael R. Freeman is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 73, co-authored 391 publications receiving 18880 citations. Previous affiliations of Michael R. Freeman include University of Virginia & Harvard University.
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Journal ArticleDOI
Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes.
Valentina R. Minciacchi,Michael R. Freeman,Dolores Di Vizio,Dolores Di Vizio,Dolores Di Vizio +4 more
TL;DR: This review summarizes recent studies on cancer-derived EV functions, with an overview about biogenesis and molecular cargo of exosomes, microvesicles and large oncosomes, and discusses current challenges and emerging technologies that might improve EV detection in various biological systems.
Journal ArticleDOI
Single photon-emission computed tomography
Thomas A. Holly,Brian G. Abbott,Mouaz H. Al-Mallah,Dennis A. Calnon,Mylan C. Cohen,Frank P. DiFilippo,Edward P. Ficaro,Michael R. Freeman,Robert C. Hendel,Diwakar Jain,Scott Leonard,Kenneth Nichols,Donna M. Polk,Prem Soman +13 more
TL;DR: The current document is an update of an earlier version of single photon emission tomography guidelines that was developed by the American Society of Nuclear Cardiology, and should not be used in clinical studies until they have been reviewed and approved by qualified physicians and technologists from their own particular institutions.
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Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts
TL;DR: The results implicate membrane cholesterol in Akt signaling in both normal and malignant cells and provide evidence that PCa cells can become dependent on a cholesterol-regulated Akt pathway for cell survival.
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Fibroblast-mediated acceleration of human epithelial tumor growth in vivo
Joseph L. Camps,Shi-Ming Chang,T. C. Hsu,Michael R. Freeman,Sung-Joon Hong,Haiyen E. Zhau,A. C. Von Eschenbach,Leland W.K. Chung +7 more
TL;DR: This tumor model may be useful in drug-screening programs and in mechanistic studies of factors regulating human tumor growth and progression and appears that undefined host factors can influence tumor growth.
Journal Article
Peripheral Blood T Lymphocytes and Lymphocytes Infiltrating Human Cancers Express Vascular Endothelial Growth Factor: A Potential Role for T Cells in Angiogenesis
Michael R. Freeman,Francis X. Schneck,Michael L. Gagnon,Christopher L. Corless,Shay Soker,Kathy Niknejad,G. E. Peoples,Michael Klagsbrun +7 more
TL;DR: The finding that peripheral T cells and TIL in human tumors synthesize a factor known to be a specific mediator of neovascularization suggests a role for T lymphocytes as cellular effectors of angiogenesis.