James McSwiggen

TL;DR: In this article, the authors present methods and reagents useful for modulating gene expression in various applications such as therapeutic, diagnostic, target assessment and genome discovery applications, which relates to synthetic chemically modified small nucleic acid molecules capable of mediating RNA interference (RNAi) to a target NCA sequence, such as short interfering nucleic acids (siNA), short interfering RNA (siRNA).

TL;DR: In this article, the authors present methods and reagents useful in modulating adenosine A1 receptor (ADORA1) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications.

TL;DR: These experiments establish the strong impact that siRNAs can have on the extent of HBV infection and underscore the importance of stabilization of siRNA against nuclease degradation.

TL;DR: In this article, a diagram of an enzymatic RNA molecule in the hammerhead motif is presented, in the motif of a hairpin, hepatitis delta virus, group I intron or RNaseP-like RNA.

TL;DR: A systematic study of selectively modified, 36-mer hammerhead ribozymes has resulted in the identification of a generic, catalytically active and nuclease stable ribozyme motif containing 5 ribose residues, 29-30 2-O-Me nucleotides, 1-2 other 2′-modified nucleotide at positions U4 and U7, and a 3′-3′-linked nucleotide “cap.”