J
James W. Collins
Researcher at Imperial College London
Publications - 21
Citations - 1213
James W. Collins is an academic researcher from Imperial College London. The author has contributed to research in topics: Citrobacter rodentium & Livestock. The author has an hindex of 17, co-authored 21 publications receiving 1010 citations. Previous affiliations of James W. Collins include Medical Research Council & Veterinary Laboratories Agency.
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Journal ArticleDOI
Citrobacter rodentium: infection, inflammation and the microbiota
James W. Collins,Kristie M. Keeney,Valerie F. Crepin,Vijay A. K. Rathinam,Katherine A. Fitzgerald,B. Brett Finlay,Gad Frankel +6 more
TL;DR: Recent studies in which C. rodentium has been used to study mucosal immunology are discussed, including the deregulation of intestinal inflammatory responses during bacteria-induced colitis and the role of the intestinal microbiota in mediating resistance to colonization by enteric pathogens.
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Use of Galleria mellonella as a model organism to study Legionella pneumophila infection.
TL;DR: Protocols for analyzing L. pneumophila virulence in the G. mellonella model are demonstrated, describing a new tool to aid the understanding of this complex pathogen.
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Legionella pneumophila Pathogenesis in the Galleria mellonella Infection Model
Clare R. Harding,Gunnar N. Schroeder,Stuart E. Reynolds,Artemis Kosta,James W. Collins,Aurelie Mousnier,Gad Frankel +6 more
TL;DR: Results suggest that G. mellonella provides an effective model to investigate the interaction between L. pneumophila and the host, and indicates that its virulence depends on protein secretion systems, in particular the Dot/Icm type IV secretion system.
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Purified galactooligosaccharide, derived from a mixture produced by the enzymic activity of Bifidobacterium bifidum, reduces Salmonella enterica serovar Typhimurium adhesion and invasion in vitro and in vivo.
Laura E. J. Searle,W. A. Cooley,Gareth Jones,Alejandro Núñez,Bentley Crudgington,Ute Weyer,Alexandra H A Dugdale,George Tzortzis,James W. Collins,Martin J. Woodward,Roberto M. La Ragione,Roberto M. La Ragione +11 more
TL;DR: The studies presented here clearly indicate that the protective effects conferred by Bimuno(®) can be attributed to GOS, and that the basal solution confers no protective effects against S. Typhimurium.
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Citrobacter rodentium mouse model of bacterial infection
TL;DR: A detailed protocol for various applications of the Citrobacter rodentium model, including bacterial growth, site-directed mutagenesis, mouse inoculation, monitoring of bacterial colonization, tissue extraction and analysis, immune responses, probiotic treatment and microbiota analysis is provided.