M
Meharvan Singh
Researcher at University of North Texas Health Science Center
Publications - 82
Citations - 6636
Meharvan Singh is an academic researcher from University of North Texas Health Science Center. The author has contributed to research in topics: Neuroprotection & Estrogen. The author has an hindex of 40, co-authored 79 publications receiving 6202 citations. Previous affiliations of Meharvan Singh include University of Florida & University of Nottingham.
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Journal ArticleDOI
ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury.
C. Dominique Toran-Allerand,Xiaoping Guan,Neil J. MacLusky,Tamas L. Horvath,Sabrina Diano,Meharvan Singh,E. Sander Connolly,Imam S. Nethrapalli,Alexander A. Tinnikov +8 more
TL;DR: It is proposed that the ER mediating activation of the MAPK cascade, a signaling pathway important for cell division, neuronal differentiation, and neuronal survival in the developing brain, is neither ER-α nor ER-β but a novel, plasma membrane-associated, putative ER with unique properties, which is designated “ER-X.”
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Estrogen-Induced Activation of Mitogen-Activated Protein Kinase in Cerebral Cortical Explants: Convergence of Estrogen and Neurotrophin Signaling Pathways
TL;DR: These novel findings provide an alternative mechanism for some of the estrogen actions in the developing CNS and could explain not only the very rapid effects of estrogen but also the ability of estrogen and neurotrophins to regulate the same broad array of cytoskeletal and growth-associated genes involved in neurite growth and differentiation.
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Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats.
TL;DR: It is hypothesized that estradiol (E2) serves as a neurotrophomodulatory substance for basal forebrain cholinergic neurons thought to be involved in learning and memory and was successful in elevating HACU relative to OVX animals in both regions.
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Novel mechanisms of estrogen action in the brain : New players in an old story
TL;DR: The much broader question of estrogen as a neural growth factor with important influences on the development, survival, plasticity, regeneration, and aging of the mammalian brain is considered and supports the view that the estrogen receptor is not only a ligand-induced transcriptional enhancer but also a mediator of rapid, nongenomic events.
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The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats.
TL;DR: The hypothesis that E2 may serve a neurotrophomodulatory role is extended by assessing the effect of OVX and E2 replacement on brain-derived nerve factor (BDNF) mRNA levels using in situ hybridization and demonstrating that E 2 deprivation leads to a reduction in BDNF mRNA.