J
James W. Spurlin
Researcher at Rice University
Publications - 14
Citations - 185
James W. Spurlin is an academic researcher from Rice University. The author has contributed to research in topics: Biology & Cornea. The author has an hindex of 7, co-authored 9 publications receiving 127 citations. Previous affiliations of James W. Spurlin include Princeton University.
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Journal ArticleDOI
Mesenchymal proteases and tissue fluidity remodel the extracellular matrix during airway epithelial branching in the embryonic avian lung.
James W. Spurlin,Michael J. Siedlik,Bryan A. Nerger,Mei-Fong Pang,Sahana Jayaraman,Rawlison Zhang,Celeste M. Nelson +6 more
TL;DR: It is found that branching morphogenesis in the embryonic chicken lung requires extracellular matrix (ECM) remodeling driven by reciprocal interactions between the epithelium and mesenchyme, and novel epithelial-mesenchymal interactions that direct ECM remodeling during airway branch morphogenesis are revealed.
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Building branched tissue structures: from single cell guidance to coordinated construction
TL;DR: Comparing mechanisms that regulate branching are compared, focusing on how cell cohorts behave in a coordinated manner to build branched tissues.
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Sema3A maintains corneal avascularity during development by inhibiting Vegf induced angioblast migration.
TL;DR: Corneal development is introduced as a new model for studying the mechanisms involved in vascular patterning during embryogenesis and it also provides new insights into therapeutic potential for Sema3A in neovascular diseases.
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A technique to increase accessibility to late-stage chick embryos for in ovo manipulations.
TL;DR: A multistep method is described that involves initially windowing eggs at E3, followed by dissecting away extraembryonic membranes at E5 to facilitate embryo accessibility in ovo until later stages of development and opens up new avenues for studying complex cellular interactions during organogenesis.
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Wounded Embryonic Corneas Exhibit Nonfibrotic Regeneration and Complete Innervation
TL;DR: Data show that minimal keratocyte activation, rapid ECM reconstruction, and proper innervation occur during nonfibrotic regeneration of the embryonic cornea.