M
Michael J. Siedlik
Researcher at Princeton University
Publications - 12
Citations - 282
Michael J. Siedlik is an academic researcher from Princeton University. The author has contributed to research in topics: Chemistry & Computer science. The author has an hindex of 6, co-authored 9 publications receiving 184 citations. Previous affiliations of Michael J. Siedlik include University of Washington & University of Pennsylvania.
Papers
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Journal ArticleDOI
Tissue Stiffness and Hypoxia Modulate the Integrin-Linked Kinase ILK to Control Breast Cancer Stem-like Cells
Mei-Fong Pang,Michael J. Siedlik,Siyang Han,Melody Stallings-Mann,Derek C. Radisky,Celeste M. Nelson +5 more
TL;DR: It is reported that stiff and hypoxic microenvironments promote the development of breast cancer stem-like cells (CSC) through modulation of the integrin-linked kinase ILK, and ILK is defined as a key mechanotransducer in modulating breast CSC development in response to tissue mechanics and oxygen tension.
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Mesenchymal proteases and tissue fluidity remodel the extracellular matrix during airway epithelial branching in the embryonic avian lung.
James W. Spurlin,Michael J. Siedlik,Bryan A. Nerger,Mei-Fong Pang,Sahana Jayaraman,Rawlison Zhang,Celeste M. Nelson +6 more
TL;DR: It is found that branching morphogenesis in the embryonic chicken lung requires extracellular matrix (ECM) remodeling driven by reciprocal interactions between the epithelium and mesenchyme, and novel epithelial-mesenchymal interactions that direct ECM remodeling during airway branch morphogenesis are revealed.
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Pushing, pulling, and squeezing our way to understanding mechanotransduction.
TL;DR: This work highlights and reviews experimental methods for investigating mechanotransduction across multiple length scales and discusses approaches for determining how molecular-scale mechanical stimuli arise in vivo in the context of complex, multicellular tissue structures.
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Microfabricated tissues for investigating traction forces involved in cell migration and tissue morphogenesis.
TL;DR: The fundamentals of traction forces, their quantification, and the use of microfabricated tissues designed to study these forces during cell migration and tissue morphogenesis are reviewed.
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Regulation of tissue morphodynamics: an important role for actomyosin contractility.
TL;DR: Recent insights into morphogenetic processes from the perspective of actomyosin contractility as a key regulator are highlighted, with emphasis on a range of results obtained through live imaging, culture, and computational methods.