J
James W. Whittaker
Researcher at Carnegie Mellon University
Publications - 23
Citations - 2587
James W. Whittaker is an academic researcher from Carnegie Mellon University. The author has contributed to research in topics: Galactose oxidase & Active site. The author has an hindex of 17, co-authored 23 publications receiving 2458 citations. Previous affiliations of James W. Whittaker include Oregon Health & Science University.
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Journal ArticleDOI
Direct electron transfer between copper-containing proteins and electrodes
Sergey Shleev,Jan Tkac,Jan Tkac,Andreas Christenson,Tautgirdas Ruzgas,Alexander I. Yaropolov,James W. Whittaker,Lo Gorton +7 more
TL;DR: It is shown that long-range electron transfer between these enzymes and electrodes can be established, and the mechanistic schemes of the DET processes are proposed.
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Glyoxal Oxidase From Phanerochaete Chrysosporium Is a New Radical-Copper Oxidase
Mei M. Whittaker,Philip J. Kersten,Nobuhumi Nakamura,Joann Sanders-Loehr,Elizabeth S. Schweizer,James W. Whittaker +5 more
TL;DR: The enzymes represent members of a growing class of free radical metalloenzymes based on the radical-copper catalytic motif and appear to represent functional variants that have evolved to distinct catalytic roles.
Journal ArticleDOI
The active site of galactose oxidase.
TL;DR: It is found that the form which has been extensively probed by EPR spectroscopy is devoid of catalytic activity and does not interact with substrate, indicating that the one-electron redox process which converts the inactive form to catalytically active enzyme is associated with oxidation of the protein rather than the metal center as has been proposed previously.
Journal ArticleDOI
A tyrosine-derived free radical in apogalactose oxidase.
TL;DR: The absence of a free radical EPR signal in reconstituted and activated galactose oxidase containing nearly stoichiometric copper suggests the radical is an active site species relating to the free radical-coupled copper site previously proposed for this enzyme.