Jamie L. Ifkovits

TL;DR: As the authors better understand biological features necessary to control cellular behavior, smarter materials are being developed that can incorporate and mimic many of these factors.

TL;DR: Investigation of injectable hyaluronic acid (MeHA) hydrogels that have tunable mechanics and gelation behavior provides fundamental information that can be used in the rational design of therapeutic materials for treatment of MI.

TL;DR: A reporter system in which the calcium indicator GCaMP is driven by the cardiomyocyte-specific Troponin T promoter is constructed and it is concluded that HNGMT produces iCMs more efficiently than previously published methods.

TL;DR: This work investigates the influence of small molecules that have been previously reported to improve differentiation to cardiomyocytes as well as reprogramming to iPSCs in conjunction with ectopic expression of the transcription factors Hand2, Nkx2.5, Gata4, Mef2C, and Tbx5 on the conversion to functional iCMs.

TL;DR: Although the experimental findings completed to date in small animals are promising, future work needs to focus on the use of large animal models in clinically relevant scenarios and to elucidate the mechanisms of these injectable hydrogels to optimize their various properties.