J
Jan A. Fischer
Researcher at University of Zurich
Publications - 180
Citations - 10469
Jan A. Fischer is an academic researcher from University of Zurich. The author has contributed to research in topics: Calcitonin gene-related peptide & Calcitonin. The author has an hindex of 53, co-authored 180 publications receiving 10261 citations. Previous affiliations of Jan A. Fischer include University Hospital of Basel & Karolinska Institutet.
Papers
More filters
Journal ArticleDOI
International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors.
David R. Poyner,Patrick M. Sexton,Ian W. Marshall,David M. Smith,Rémi Quirion,Walter Born,Roman Muff,Jan A. Fischer,Steven M. Foord +8 more
TL;DR: A review of the calcitonin family of peptides aims to reconcile what is observed when the receptors are reconstituted in vitro with the properties they show in native cells and tissues.
Journal ArticleDOI
Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells.
G. Ju,Tomas Hökfelt,Ernst Brodin,Jan Fahrenkrug,Jan A. Fischer,Peter Frey,Robert Elde,John C. Brown +7 more
TL;DR: The present results indicate that a CGRP-like peptide is present in a wide range of primary sensory neurons probably not related to specific sensory modalities and often this peptide coexists with other biologically active peptides.
Journal ArticleDOI
Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin
TL;DR: The functional analysis revealed that CGRP caused cardiac stimulation and had, together with SP and neurokinin A, potent hypotensive effects, and the bronchial smooth muscle was particularly sensitive to neurokinIn A.
Journal ArticleDOI
Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat
Z. Wiesenfeld-Hallin,Tomas Hökfelt,Jan M. Lundberg,W.G. Forssmann,M. Reinecke,Fritz A. Tschopp,Jan A. Fischer +6 more
TL;DR: Analysis of caudally directed biting and scratching behavior after intrathecal administration of CGRP and SP alone or in combination provides support for a possible interaction of the two peptides at synapses in the dorsal horn of the spinal cord.
Journal ArticleDOI
Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin.
Anders Franco-Cereceda,Hermann Henke,Jan M. Lundberg,Josef B. Petermann,Tomas Hökfelt,Jan A. Fischer +5 more
TL;DR: The presence of calcitonin-gene related peptide (CGRP)-like immunoreactivity (-LI) in sensory neurons was established by immunohistochemistry and radioimmunoassay (RIA) in combination with high performance liquid chromatography (HPLC).