Journal ArticleDOI
Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells.
G. Ju,Tomas Hökfelt,Ernst Brodin,Jan Fahrenkrug,Jan A. Fischer,Peter Frey,Robert Elde,John C. Brown +7 more
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TLDR
The present results indicate that a CGRP-like peptide is present in a wide range of primary sensory neurons probably not related to specific sensory modalities and often this peptide coexists with other biologically active peptides.Abstract:
By use of the indirect immunofluorescence technique the distribution of calcitonin gene-related peptide (CGRP)-like immunoreactivity (LI) has been analyzed in cervical and lumbar dorsal root ganglia of untreated and colchicine-treated rats. In addition, lumbar ganglia were examined 2 weeks after transection of the sciatic nerve. The occurrence of CGRP-positive cells in relation to ganglion cells containing substance P-, somatostatin-, galanin-, cholecystokinin (CCK)-, and vasoactive intestinal polypeptide (VIP)/peptide histidine isoleucin (PHI)-LI has been evaluated on consecutive sections as well as using elution-restaining and double-staining techniques.read more
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Nociception from skeletal muscle in relation to clinical muscle pain.
Journal ArticleDOI
Neuroanatomical Localization, Pharmacological Characterization and Functions of CGRP, Related Peptides and Their Receptors
TL;DR: Findings on the anatomical distributions of CGRP mRNA, C GRP-like immunoreactivity and receptors in the central nervous system, as well as the potential physiological roles for CGRp are discussed.
Journal ArticleDOI
Neuropeptide expression in rat dorsal root ganglion cells and spinal cord after peripheral nerve injury with special reference to galanin.
Marcelo J. Villar,R. Cortés,Elvar Theodorsson,Zsuzsanna Wiesenfeld-Hallin,Martin Schalling,Jan Fahrenkrug,Piers C. Emson,Tomas Hökfelt +7 more
TL;DR: The results demonstrate that when primary sensory neurons are peripherally lesioned they respond in a complex manner, altering their normal production of peptides by increasing or decreasing their synthesis.
Journal ArticleDOI
Tachykinins and calcitonin gene-related peptide (CGRP) as co-transmitters released from peripheral endings of sensory nerves
TL;DR: Neuroeffector roles of tachykinins and CGRP released from primary afferent neurons 6.2.1 Pathoph:ysiological implications 6.3.1.
Journal ArticleDOI
Increase of galanin-like immunoreactivity in rat dorsal root ganglion cells after peripheral axotomy.
TL;DR: Some primary sensory neurons react to transection of their peripheral branches by expressing increased GAL levels, and this reaction has been described by other groups for vasoactive intestinal polypeptide.
References
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Journal ArticleDOI
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Michael G. Rosenfeld,Jean-Jacques Mermod,Susan G. Amara,Larry W. Swanson,Paul E. Sawchenko,Jean Rivier,Wylie Vale,Ronald M. Evans +7 more
TL;DR: The approach described here permits the application of recombinant DNA technology to analyses of complex neurobiological systems in the absence of prior structural or biological information.
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Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
TL;DR: A model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression is proposed.
Journal ArticleDOI
A simple method of reducing the fading of immunofluorescence during microscopy
Journal ArticleDOI
Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species
S.J. Gibson,J.M. Polak,Stephen R. Bloom,I.M. Sabate,PM Mulderry,M. A. Ghatei,Gerard P. McGregor,J.F.B. Morrison,JS Kelly,Ronald M. Evans +9 more
TL;DR: The selective distribution of CGRP throughout sensory, motor, and autonomic areas of the spinal cord suggests many putative roles for this novel peptide.