J
Jan C. M. van Hest
Researcher at Eindhoven University of Technology
Publications - 329
Citations - 20247
Jan C. M. van Hest is an academic researcher from Eindhoven University of Technology. The author has contributed to research in topics: Polymersome & Chemistry. The author has an hindex of 68, co-authored 307 publications receiving 17125 citations. Previous affiliations of Jan C. M. van Hest include Ulsan National Institute of Science and Technology & University of Massachusetts Amherst.
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Journal ArticleDOI
Sub‐Micron Polymeric Stomatocytes as Promising Templates for Confined Crystallization and Diffraction Experiments
TL;DR: It is expected that the encapsulation and crystallization within these compartments can be considered as a promising template (nanovials) that hold and protect nanocrystals and protein clusters from the direct radiation damage before data acquisition, while they are examined by modern crystallography methodologies such as serial femtosecond crystallography.
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Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three‐Dimensional Imaging of Living Cells
Jan Dommerholt,Samuel Schmidt,Rinske P. Temming,Linda J.A. Hendriks,Floris P. J. T. Rutjes,Jan C. M. van Hest,Dirk Lefeber,Peter Friedl,Floris L. van Delft +8 more
TL;DR: Symmetrical BCN derivatives display excellent reaction kinetics in strain-promotedcycloaddition reactions and were applied in the labeling of proteins and glycans, as well as in the three-dimensional visualization of living melanomacells.
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Modular synthesis of block copolymers via cycloaddition of terminal azide and alkyne functionalized polymers.
TL;DR: Polymeric building blocks containing terminal azide and alkyne functionalities are prepared via atom transfer radical polymerization (ATRP) and used to modularly synthesize block copolymers via 1,3-dipolar cycloaddition reactions, which are quantitative according to SEC measurements.
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Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition.
Marjoke F. Debets,Sander S. van Berkel,Sanne Schoffelen,Floris P. J. T. Rutjes,Jan C. M. van Hest,Floris L. van Delft +5 more
TL;DR: Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.
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Autonomous movement of platinum-loaded stomatocytes
TL;DR: An approach to generate autonomous movement of the polymer stomatocytes by selectively entrapping catalytically active platinum nanoparticles within their nanocavities and subsequently using catalysis as a driving force for movement is reported.