https://www.researchgate.net/file.PostFileLoader.html?id=526892a1d4c118a61d4360bd&assetKey=AS%3A272155479085058%401441898330516

Porosity of 3D biomaterial scaffolds and osteogenesis.

Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible. Implementation of such devices requires the use of biocompatible materials that are susceptible to a specific physical incitement or that, in response to a specific stimulus, undergo a protonation, a hydrolytic cleavage or a (supra)molecular conformational change. In this Review, we discuss recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).

Stimuli-responsive nanocarriers for drug delivery

Hydrogels for tissue engineering.

https://imechanica.org/files/Qiu_environmental_sensitive_hydrogel.pdf

Environment-sensitive hydrogels for drug delivery

Freedom of design, mass customisation, waste minimisation and the ability to manufacture complex structures, as well as fast prototyping, are the main benefits of additive manufacturing (AM) or 3D printing. A comprehensive review of the main 3D printing methods, materials and their development in trending applications was carried out. In particular, the revolutionary applications of AM in biomedical, aerospace, buildings and protective structures were discussed. The current state of materials development, including metal alloys, polymer composites, ceramics and concrete, was presented. In addition, this paper discussed the main processing challenges with void formation, anisotropic behaviour, the limitation of computer design and layer-by-layer appearance. Overall, this paper gives an overview of 3D printing, including a survey on its benefits and drawbacks as a benchmark for future research and development.

Additive manufacturing (3D printing): A review of materials, methods, applications and challenges

https://pure.hw.ac.uk/ws/files/10766137/Melchels2010_Biomaterials_31_24_6121.pdf

A review on stereolithography and its applications in biomedical engineering

https://ris.utwente.nl/ws/files/6775659/Witte96phase.pdf

Phase-Separation Processes in Polymer-Solutions in Relation to Membrane Formation

Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery.

Stimuli-responsive polymersomes for programmed drug delivery.

DSC was performed on aqueous solutions of poly(N-isopropylecrylamide-co-butyl methacrylate-co-X), with X being hydrophilic, hydrophobic, cationic, or anionic comonomers, to elucidate the mechanism of temperature-induced phase separation and the effect of comonomer content, hydrophilicity, and charge on the lower critical solution temperature (LCST). The endothermic heat of phase separation, which is related to the breaking of hydrogen bonds between water molecules surrounding hydrophobic moieties on the polymer, was a linear, decreasing function of the LCST. This suggests that the hydrophobic interactions between polymer side groups, which are the major driving force for phase separation, ere enhanced at elevated temperatures due to a decrease in the structuring of water around hydrophobic side groups

Jan Feijen

Papers

A review on stereolithography and its applications in biomedical engineering

Phase-Separation Processes in Polymer-Solutions in Relation to Membrane Formation

Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery.

Stimuli-responsive polymersomes for programmed drug delivery.

Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers