Showing papers in "Journal of Controlled Release in 2011"

TL;DR: It would be profitable to address a variety of issues and factors that could affect the development of improved targeted drug delivery systems, including nanocarrier, nanovehicle, nanosystem, nanostructure, and other terms used in the literature.

TL;DR: This review summarizes emerging efforts in combating against infectious diseases, particularly using antimicrobial NPs and antibiotics delivery systems as new tools to tackle the current challenges in treating infectious diseases.

TL;DR: In this article, the authors introduced several mechanisms and agents which are involved in endosomal escape, including pore formation, pH buffering effect of protonable groups and fusion into the lipid bilayer of endosomes.

TL;DR: This paper will review recent results on GSH-responsive nano-vehicles in particular micelles, nanoparticles, capsules, polymersomes, nanogels, dendritic and macromolecular drug conjugates, and nano-sized nucleic acid complexes for controlled delivery of anti-cancer drugs and nucleic acids.

TL;DR: Recent advances in the use of gold nanoparticles in drug and gene delivery systems are reviewed and the topics of surface modification, site-specificity and drugs and gene and Gene delivery are discussed.

TL;DR: Advances in the use of semiconductor fluorescent quantum dots, carbon nanotubes, gold nanoparticles, iron oxide magnetic nanoparticles and ceramic nanoparticles in tumor targeting, imaging, photothermal therapy and drug delivery applications are discussed.

TL;DR: The physiological challenges as well as the advances and opportunities for buccal/sublingual drug delivery are highlighted, with particular attention given to new approaches which can extend dosage form retention time or can be engineered to deliver complex molecules such as proteins and peptides.

TL;DR: The most important factors to be taken into account when developing a formulation based on hydrophilic matrices are the percentage, solubility and drug particle size; the type of polymer, the percentage incorporated, its degree of viscosity and the polymer particle size.

TL;DR: Silk fibroin (SF), a naturally occurring protein polymer, has several unique properties making it a favorable matrix for the incorporation and delivery of a range of therapeutic agents.

TL;DR: It can be concluded that casein-based formulations are promising materials for controlled drug delivery.

TL;DR: A hyaluronan (HA)-based synthetic extracellular matrix (sECM) that provides highly reproducible, manufacturable, approvable, and affordable biomaterials for cell therapy and the development of clinical combination products is created.

TL;DR: In the breast and pancreatic cancer animal models, ultrasound-mediated therapy with paclitaxel-loaded PFCE nanoemulsions showed excellent therapeutic properties characterized by tumor regression and suppression of metastasis.

TL;DR: This review presents the recent trends in the synthesis of functional aliphatic polyesters and their application for protein delivery and tissue engineering.

TL;DR: The use of ultrasound for the delivery of drugs to, or through, the skin is commonly known as sonophoresis or phonophoreis as mentioned in this paper, and the mechanisms associated with each physical enhancer are different.

TL;DR: Temperature-sensitive liposomes co-encapsulating doxorubicin and 250 mM [Gd(HPDO3A)(H₂O)] were evaluated for HIFU-mediated drug delivery under MR image guidance and a good correlation between the ΔR₁, the uptake and the gadolinium concentration in the tumor was found.

TL;DR: The developed QD-MUC1-DOX conjugate had higher cytotoxicity than free DOX in multidrug resistant cancer cells and preferentially accumulated in ovarian tumor.

TL;DR: This review offers a comprehensive overview of current knowledge of the major theoretical as well as practical aspects of mRNA-mediated transfection, showing both its possibilities and its pitfalls and should therefore be useful for a diverse scientific audience.

TL;DR: By varying the particle size, different sites within the porcine hair follicle can be targeted selectively, and the situation can be expected to be similar due to a similar size ratio of the hair follicles.

TL;DR: The fabrication and characterization of a drug-loaded iron oxide nanoparticle designed to circumventMultidrug resistance is described and it is suggested that DOX-conjugated nanoparticles could improve the efficacy of chemotherapy by circumventing MDR.

TL;DR: Overall, this study showed that pre-treatment of skin with microneedles before applying an occlusive transdermal patch can increase skin permeability for more than one day, but nonetheless allow skin to reseal rapidly after patch removal.

TL;DR: An affinity-based growth factor delivery system by incorporating heparin into photocrosslinkable alginate hydrogels (HP-ALG), which allows for controlled, prolonged release of therapeutic proteins and may provide a powerful modality for a variety of therapeutic applications.

TL;DR: The objective of this review is to provide an update on different engineering strategies employed to achieve optimum polymeric micellar formulations.

TL;DR: This review enumerates various strategies which are employed in the modification and conjugation of antibodies to the surface of stealth liposomes and describes various derivatization techniques of lipids prior and after their use in the preparation of liposome.

TL;DR: Systemic delivery of specific siRNA by nanoparticles significantly inhibited luciferase expression in an orthotopic murine liver cancer model and suppressed tumor growth in a MDA-MB-435s murine xenograft model, suggesting its therapeutic promise in disease treatment.

TL;DR: Findings have major implications for the use of HA in nanomedicine as LMw-HA surface modified-NPs could be a viable option for the replacement of polyethylene glycol (PEG) when passive delivery is required, lacking adverse effects such as complement activation and cytokine induction.

TL;DR: Comparison studies with drug-loaded and drug-conjugated nanoparticles showed that the photosensitizer- Conjugated glycol chitosan nanoparticles with excellent tumor targeting properties have potential for PDT in cancer treatment.

TL;DR: The result suggests that novel HA hydrogels could be used as a BMP-2 carrier and can promote bone augmentation for potential orthopedic applications.

TL;DR: The results indicate that the volume phase transition temperature (VPTT), thermally induced deswelling ratio, and acid-triggered swelling ratio of the nanogels are closely relevant to their compositions and crosslinking degrees.

TL;DR: OL-NPs could be potentially used as carriers for nose-to-brain drug delivery, especially for macromolecular drugs, in the treatment of CNS disorders.

TL;DR: Drug and vaccine delivery using arrowhead microneedles are designed to offer a quick, convenient, safe and potentially self-administered method of drug delivery as an alternative to hypodermic needles.