J
Jan Pačes
Researcher at Academy of Sciences of the Czech Republic
Publications - 58
Citations - 2795
Jan Pačes is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 30, co-authored 54 publications receiving 2530 citations. Previous affiliations of Jan Pačes include Institute of Chemical Technology in Prague.
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Long-term reinfection of the human genome by endogenous retroviruses.
Robert Belshaw,Vini Pereira,Aris Katzourakis,Gillian Talbot,Jan Pačes,Austin Burt,Michael Tristem +6 more
TL;DR: This finding strongly suggests that the proliferation of the human ERV family HERV-K(HML2) has been almost entirely due to germ-line reinfection, rather than retrotransposition in cis or complementation in trans, and that an infectious pool of endogenous retroviruses has persisted within the primate lineage throughout the past 30 million years.
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Characterization of an amphioxus paired box gene, AmphiPax2/5/8: developmental expression patterns in optic support cells, nephridium, thyroid-like structures and pharyngeal gill slits, but not in the midbrain-hindbrain boundary region
TL;DR: The developmental expression of AmphiPax2/5/8 indicates that the amphioxus central nervous system lacks a MHB resembling the vertebrate isthmic region.
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High Copy Number in Human Endogenous Retrovirus Families is Associated with Copying Mechanisms in Addition to Reinfection
TL;DR: Analysis of the evolution of 17 HERV families using d(N)/d(S) ratios finds a positive relationship between copy number and the use of additional copying mechanisms and discusses why these other mechanisms are rare in most families.
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Processed Pseudogenes of Human Endogenous Retroviruses Generated by LINEs: Their Integration, Stability, and Distribution
TL;DR: It is suggested that HERV-W processed pseudogenes arose by multiple and independent LINE-mediated retrotransposition of retroviral mRNA, and that the majority of HERv-W copies are actually nontranscribed promoterless Pseudogenes.
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Similar integration but different stability of Alus and LINEs in the human genome.
TL;DR: The present results on Alu and LINE stability/exclusion predict significant losses of Alu DNA from the GC-poor isochores during evolution, a phenomenon apparently due to negative selection against sequences that differ from the isochore composition.