V
Václav Pačes
Researcher at Academy of Sciences of the Czech Republic
Publications - 70
Citations - 2491
Václav Pačes is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Gene & Nucleic acid sequence. The author has an hindex of 30, co-authored 70 publications receiving 2361 citations. Previous affiliations of Václav Pačes include Czechoslovak Academy of Sciences & Institute of Chemical Technology in Prague.
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Journal ArticleDOI
Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers.
Claudia A. L. Ruivenkamp,Tom van Wezel,Carlo Zanon,Alphons P. M. Stassen,Čestmír Vlček,Tamás Csikós,Anita M. Klous,Nikos Tripodis,Anastassis Perrakis,Lucie Boerrigter,Peter C. Groot,Jan H.N. Lindeman,Wolter J. Mooi,Gerrit A. Meijjer,Gert Scholten,Hans G. Dauwerse,Václav Pačes,Nico van Zandwijk,Gert-Jan B. van Ommen,Peter Demant +19 more
TL;DR: The positional cloning of the mouse gene Scc1 (Susceptibility to colon cancer 1) and the identification of Ptprj, encoding a receptor-type protein tyrosine phosphatase, as the underlying gene are reported and suggest that PTPRJ is relevant to the development of several different human cancers.
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Assembly of the cnidarian camera-type eye from vertebrate-like components
Zbynek Kozmik,Jana Ruzickova,Kristyna Jonasova,Yoshifumi Matsumoto,Pavel Vopalensky,Iryna Kozmikova,Hynek Strnad,Shoji Kawamura,Joram Piatigorsky,Václav Pačes,Čestmír Vlček +10 more
TL;DR: It is shown that camera-type eyes of the cubozoan jellyfish, Tripedalia cystophora, use genetic building blocks typical of vertebrate eyes, namely, a ciliary phototransduction cascade and melanogenic pathway.
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Similar integration but different stability of Alus and LINEs in the human genome.
TL;DR: The present results on Alu and LINE stability/exclusion predict significant losses of Alu DNA from the GC-poor isochores during evolution, a phenomenon apparently due to negative selection against sequences that differ from the isochore composition.
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The human cystathionine β-synthase (CBS) gene : complete sequence, alternative splicing, and polymorphisms
Jan P. Kraus,Jana Oliveriusová,Jana Oliveriusová,Jitka Sokolová,Eva Kraus,Čestmı ́r Vlček,Raffaella de Franchis,Kenneth N. Maclean,Liming Bao,Gabriela Bukovská,David Patterson,Václav Pačes,Wilhelm Ansorge,Viktor Kožich +13 more
TL;DR: The molecular cloning and the complete nucleotide sequence of the human CBS gene is described and the identification of two alternatively used promoter regions that are GC rich (approximately 80%) and contain numerous putative binding sites for Sp1, Ap 1, Ap2, and c-myb, but lack the classical TATA box.
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Identification and tissue distribution of human cystathionine beta-synthase mRNA isoforms.
TL;DR: PCR-based quantitative analyses of CBS mRNA isoforms in human liver demonstrate that CBS 1 and CBS 2 are the major species, with CBS 2 being more abundant, while CBS 3-5 are the minor species.