Preface to the Princeton Landmarks in Biology Edition vii Preface xi Symbols Used xiii 1. The Importance of Islands 3 2. Area and Number of Speicies 8 3. Further Explanations of the Area-Diversity Pattern 19 4. The Strategy of Colonization 68 5. Invasibility and the Variable Niche 94 6. Stepping Stones and Biotic Exchange 123 7. Evolutionary Changes Following Colonization 145 8. Prospect 181 Glossary 185 References 193 Index 201

The Theory of Island Biogeography

The principles of classification and a classification of mammals. Bulletin of the AMNH ; v. 85

This report summarizes the international divisions and ages in the Geologic Time Scale, published
in 2012 (GTS2012). Since 2004, when GTS2004 was detailed, major developments have taken place
that directly bear and have considerable impact on the intricate science of geologic time scaling. Precam brian
now has a detailed proposal for chronostratigraphic subdivision instead of an outdated and abstract chronometric
one. Of 100 chronostratigraphic units in the Phanerozoic 63 now have formal definitions, but stable
chronostratigraphy in part of upper Paleozoic, Triassic and Middle Jurassic/Lower Cretaceous is still wanting.
Detailed age calibration now exist between radiometric methods and orbital tuning, making 40Ar-39Ar dates
0.64% older and more accurate. In general, numeric uncertainty in the time scale, although complex and not
entirely amenable to objective analysis, is improved and reduced. Bases of Paleozoic, Mesozoic and Cenozoic
are bracketed by analytically precise ages, respectively 541 0.63, 252.16 0.5, and 65.95 0.05 Ma.
High-resolution, direct age-dates now exist for base-Carboniferous, base-Permian, base-Jurassic, base-Cenomanian
and base-Eocene. Relative to GTS2004, 26 of 100 time scale boundaries have changed age, of which
14 have changed more than 4 Ma, and 4 (in Middle to Late Triassic) between 6 and 12 Ma. There is much
higher stratigraphic resolution in Late Carboniferous, Jurassic, Cretaceous and Paleogene, and improved integration
with stable isotopes stratigraphy. Cenozoic and Cretaceous have a refined magneto-biochronology.
The spectacular outcrop sections for the Rosello Composite in Sicily, Italy and at Zumaia, Basque Province,
Spain encompass the Global Boundary Stratotype Sections and Points for two Pliocene and two Paleocene
stages. Since the cycle record indicates, to the best of our knowledge that the stages sediment fill is stratigraphically
complete, these sections also may fulfill the important role of stage unit stratotypes for three of
these stages, Piacenzian, Zanclean and Danian

On The Geologic Time Scale

Absolute metabolite concentrations are critical to a quantitative understanding of cellular metabolism, as concentrations impact both the free energies and rates of metabolic reactions. Here we use LC-MS/MS to quantify more than 100 metabolite concentrations in aerobic, exponentially growing Escherichia coli with glucose, glycerol or acetate as the carbon source. The total observed intracellular metabolite pool was approximately 300 mM. A small number of metabolites dominate the metabolome on a molar basis, with glutamate being the most abundant. Metabolite concentration exceeds K(m) for most substrate-enzyme pairs. An exception is lower glycolysis, where concentrations of intermediates are near the K(m) of their consuming enzymes and all reactions are near equilibrium. This may facilitate efficient flux reversibility given thermodynamic and osmotic constraints. The data and analyses presented here highlight the ability to identify organizing metabolic principles from systems-level absolute metabolite concentration data.

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

An Astronomically Tuned Neogene Time Scale (ATNTS2012) is presented, as an update of ATNTS2004 in GTS2004. The new scale is not fundamentally different from its predecessor and the numerical ages are identical or almost so. Astronomical tuning has in principle the potential of generating a stable Neogene time scale as a function of the accuracy of the La2004 astronomical solution used for both scales. Minor problems remain in the tuning of the Lower Miocene. In GTS2012 we will summarize what has been modified or added since the publication of ATNTS2004 for incorporation in its successor, ATNTS2012. Mammal biostratigraphy and its chronology are elaborated, and the regional Neogene stages of the Paratethys and New Zealand are briefy discussed. To keep changes to ATNTS2004 transparent we maintain its subdivision into headings as much as possible.

The Neogene Period

Mammals are among the fastest-radiating groups, being characterized by a mean species lifespan of the order of 2.5 million years (Myr). The basis for this characteristic timescale of origination, extinction and turnover is not well understood. Various studies have invoked climate change to explain mammalian species turnover , but other studies have either challenged or only partly confirmed the climate–turnover hypothesis. Here we use an exceptionally long (24.5–2.5Myr ago), dense, and welldated terrestrial record of rodent lineages from central Spain, and show the existence of turnover cycles with periods of 2.4–2.5 and 1.0Myr. We link these cycles to low-frequency modulations of Milankovitch oscillations, and show that pulses of turnover occur at minima of the 2.37-Myr eccentricity cycle and nodes of the 1.2-Myr obliquity cycle. Because obliquity nodes and eccentricity minima are associated with ice sheet expansion and cooling and affect regional precipitation, we infer that long-period astronomical climate forcing is a major determinant of species turnover in small mammals and probably other groups as well.

/pdf/long-period-astronomical-forcing-of-mammal-turnover-1tk4bpppjz.pdf

Long-period astronomical forcing of mammal turnover

Geographic and temporal patterns in the late Neogene (12¿3 Ma) aridification of Europe: The use of small mammals as paleoprecipitation proxies

Reconstruction of the Late Miocene climate of Spain using rodent palaeocommunity successions: an application of end-member modelling

The in vivo kinetics in Saccharomyces cerevisiae CEN.PK 113-7D was evaluated during a 300-second transient period after applying a glucose pulse to an aerobic, carbon-limited chemostat culture. We quantified the responses of extracellular metabolites, intracellular intermediates in primary metabolism, intracellular free amino acids, and in vivo rates of O2 uptake and CO2 evolution. With these measurements, dynamic carbon, electron, and ATP balances were set up to identify major carbon, electron, and energy sinks during the postpulse period. There were three distinct metabolic phases during this time. In phase I (0 to 50 seconds after the pulse), the carbon/electron balances closed up to 85%. The accumulation of glycolytic and storage compounds accounted for 60% of the consumed glucose, caused an energy depletion, and may have led to a temporary decrease in the anabolic flux. In phase II (50 to 150 seconds), the fermentative metabolism gradually became the most important carbon/electron sink. In phase III (150 to 300 seconds), 29% of the carbon uptake was not identified in the measurements, and the ATP balance had a large surplus. These results indicate an increase in the anabolic flux, which is consistent with macroscopic balances of extracellular fluxes and the observed increase in CO2 evolution associated with nonfermentative metabolism. The identified metabolic processes involving major carbon, electron, and energy sinks must be taken into account in in vivo kinetic models based on short-term dynamic metabolome responses.

Short-Term Metabolome Dynamics and Carbon, Electron, and ATP Balances in Chemostat-Grown Saccharomyces cerevisiae CEN.PK 113-7D following a Glucose Pulse

Jan van Dam

Papers

The Neogene Period

Long-period astronomical forcing of mammal turnover

Geographic and temporal patterns in the late Neogene (12¿3 Ma) aridification of Europe: The use of small mammals as paleoprecipitation proxies

Reconstruction of the Late Miocene climate of Spain using rodent palaeocommunity successions: an application of end-member modelling

Short-Term Metabolome Dynamics and Carbon, Electron, and ATP Balances in Chemostat-Grown Saccharomyces cerevisiae CEN.PK 113-7D following a Glucose Pulse