J
Jane McCarthy
Researcher at University College Cork
Publications - 28
Citations - 2642
Jane McCarthy is an academic researcher from University College Cork. The author has contributed to research in topics: Inflammatory bowel disease & Ulcerative colitis. The author has an hindex of 11, co-authored 25 publications receiving 2454 citations. Previous affiliations of Jane McCarthy include National University of Ireland.
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Journal ArticleDOI
Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles
Liam O'Mahony,Jane McCarthy,Peter Kelly,George J Hurley,Fangyi Luo,Ker-Sang Chen,Gerald C. O'Sullivan,Barry Kiely,J. Kevin Collins,Fergus Shanahan,Eamonn Martin Quigley +10 more
TL;DR: B infantis 35624 alleviates symptoms in IBS; this symptomatic response was associated with normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine, suggesting an immune-modulating role for this organism, in this disorder.
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Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance
Jane McCarthy,Liam O'Mahony,L. O'Callaghan,B. Sheil,Elaine E. Vaughan,N.A. Fitzsimons,J. Fitzgibbon,Gerald C. O'Sullivan,Barry Kiely,John Kevin Collins,Fergus Shanahan +10 more
TL;DR: Both Lactobacillus salivarius and Bifidobacterium infantis 35624 significantly attenuate colitis in this murine model, associated with a reduced ability to produce Th1-type cytokines systemically and mucosally while levels of TGF-β are maintained.
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Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis.
B. Sheil,Jane McCarthy,Liam O'Mahony,Michael W. Bennett,Paul Ryan,J. Fitzgibbon,Barry Kiely,John Kevin Collins,Fergus Shanahan +8 more
TL;DR: Subcutaneous administration of L salivarius 118 significantly attenuated colitis in the IL-10 KO model and suppressed collagen induced arthritis, suggesting that the oral route may not be essential for probiotic anti-inflammatory effects and that responses are not disease specific.
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Combining proteolytic and phloroglucinol-producing bacteria for improved biocontrol of Pythium-mediated damping-off of sugar beet
Colum P. Dunne,Yvan Moënne-Loccoz,Jane McCarthy,P. Higgins,James A. Powell,David N. Dowling,Fergal O'Gara +6 more
TL;DR: The combined use of a phloroglucinol-producing P. fluorescens and a proteolytic S. maltophilia improved protection of sugar beet against Pythium-mediated damping-off when compared with single inoculations of either biocontrol strain.
Journal ArticleDOI
Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in different lymphoid compartments in humans.
Liam O'Mahony,L. O'Callaghan,Jane McCarthy,David Shilling,Paul Scully,Shomik Sibartie,E. G. Kavanagh,William O. Kirwan,Henry Paul Redmond,John Kevin Collins,Fergus Shanahan +10 more
TL;DR: Commensal bacteria induced regulatory cytokine production by MLN cells, whereas pathogenic bacteria induce T cell helper 1-polarizing cytokines, which is more marked in cells isolated from the mucosal immune system compared with PBMCs.