Janet M. Rozovics

TL;DR: It is revealed that the nsp1 induced endonucleolytic RNA cleavage mainly near the 5′ untranslated region of capped mRNA templates, which may be an important strategy by which the virus circumvents the action of nsp 1 leading to the efficient accumulation of viral mRNAs and viral proteins during infection.

TL;DR: The purification and identification of VPg unlinkase as the DNA repair enzyme, 5′-tyrosyl–DNA phosphodiesterase-2 (TDP2) is reported, revealing a unique RNA repair-like function for TDP2 and suggesting an unusual role in host–pathogen interactions for this cellular enzyme.

TL;DR: The data suggested that HeLa cell extracts and cultured host cells, but not RRL, contain a host factor(s) that is essential for TGEV nsp1-induced translational suppression.

TL;DR: It is demonstrated that all four isoforms of AUF1 bind directly to stem-loop IV of the poliovirus 5′ NCR, an interaction that is inhibited through proteolytic cleavage ofAUF1 by the viral proteinase 3CD.

TL;DR: Experiments suggest that AUF1, a host RNA binding protein involved in mRNA decay, plays a role in the infectious cycle of picornaviruses such as poliovirus and human rhinovirus and how small RNA viruses manipulate the activities of host cell RNA binding proteins to ensure a faithful intracellular replication cycle is illuminated.