Janet S. Kerr

TL;DR: Findings provide evidence that PECAM-1 is involved in angiogenesis and suggest that the interactions of endothelial cell-cell adhesion molecules are important in the formation of new vessels.

TL;DR: DuP 697 (5-bromo-2[4-fluorophenyl]-3-[4-methylsulfonylphenyl]-thiophene) is a potent inhibitor of paw swelling in nonestablished and established adjuvant arthritis in rats (ED50 = 0.03 and 0.18 mg/kg/day, respectively).

TL;DR: A series of 2'-substituted chalcone derivatives has been found to show potent inhibition of the production of IL-1 beta from human peripheral blood monocytes stimulated with lipopolysaccharide, suggesting a degree of selectivity which would not be expected for simple, nonspecific alkylating agents.

TL;DR: The effects of recombinant interleukin-1 beta (rIL-1beta) on phospholipase A2 activity (PLA2), PLA2 messenger RNA levels, and eicosanoid production in rabbit chondrocytes are investigated.

TL;DR: It is demonstrated that early murine Lyme carditis requires neither class II antigen expression nor presentation of antigen to CD4+ T lymphocytes and suggested a direct response of macrophages to cardiac tissue invasion by B. burgdorferi.