R
Robert Newton
Researcher at University of Calgary
Publications - 150
Citations - 10001
Robert Newton is an academic researcher from University of Calgary. The author has contributed to research in topics: Glucocorticoid & Glucocorticoid receptor. The author has an hindex of 57, co-authored 150 publications receiving 9493 citations. Previous affiliations of Robert Newton include University of Warwick & National Institutes of Health.
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Journal ArticleDOI
Molecular mechanisms of glucocorticoid action: what is important?
TL;DR: The ability to suppress a number of inflammatory indices makes glucocorticoids among the most potent anti-inflammatory agents currently available for the treatment of chronic inflammatory diseases such as asthma.
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Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β ☆
TL;DR: It is concluded that IL-1β stimulates PG production via transcriptional activation of COX-2 and evidence that this may involve NF-κB is provided.
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Anti-inflammatory Effects of Resveratrol in Lung Epithelial Cells: Molecular Mechanisms
Louise E. Donnelly,Robert Newton,Gina E. Kennedy,Peter Fenwick,Rachel H. F. Leung,Kazuhiro Ito,Richard Russell,Peter J. Barnes +7 more
TL;DR: It is demonstrated that resveratrol and quercetin have novel nonsteroidal anti-inflammatory activity that may have applications for the treatment of inflammatory diseases.
Journal ArticleDOI
Separating Transrepression and Transactivation: A Distressing Divorce for the Glucocorticoid Receptor?
Robert Newton,Neil S. Holden +1 more
TL;DR: It is presented the case that mechanistically distinct forms of glucocorticoid-inducible gene expression are critical to the development of anti-inflammatory effects by repressing inflammatory signaling pathways and inflammatory gene expression at multiple levels.
Journal ArticleDOI
Human labour is associated with nuclear factor-κB activity which mediates cyclo-oxygenase-2 expression and is involved with the ‘functional progesterone withdrawal’
Victoria C. Allport,Doris Pieber,Donna M. Slater,Robert Newton,J.O. White,Phillip R. Bennett +5 more
TL;DR: It is suggested that human labour is associated with constitutive NF-kappaB activity within the amnion, which functions to increase the expression of COX-2 and appears to contribute to the 'functional progesterone withdrawal'.