J
Janis Arrigoni
Researcher at Stanford University
Publications - 10
Citations - 932
Janis Arrigoni is an academic researcher from Stanford University. The author has contributed to research in topics: Narcolepsy & Cataplexy. The author has an hindex of 10, co-authored 10 publications receiving 908 citations.
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Journal ArticleDOI
Validation of a Cataplexy Questionnaire in 983 Sleep-disorders Patients
Svetlana Anic-Labat,Christian Guilleminault,Helena C. Kraemer,Jennifer Meehan,Janis Arrigoni,Emmanuel Mignot +5 more
TL;DR: Cataplexy was best differentiated from other types of muscle weakness when triggered by only three typical situations: "when hearing and telling a joke," "while laughing," or "when angry."
Journal ArticleDOI
DQB1*0602 and DQA1*0102 (DQ1) Are Better Markers Than DR2 for Narcolepsy in Caucasian and Black Americans
Emmanuel Mignot,X. Lin,Janis Arrigoni,Claudia Macaubas,F Olive,Joachim Hallmayer,Peter A. Underhill,Christian Guilleminault,W C Dement,F. C. Grumet +9 more
TL;DR: It is demonstrated that DQB1*0602/DQA1*0102 is the best marker for narcolepsy across all ethnic groups.
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Canine cataplexy is preferentially controlled by adrenergic mechanisms: evidence using monoamine selective uptake inhibitors and release enhancers
Emmanuel Mignot,Alain Renaud,Seiji Nishino,Janis Arrigoni,Christian Guilleminault,William C. Dement +5 more
TL;DR: The results demonstrate the preferential involvement of adrenergic systems in the control of cataplexy and, presumably, REM sleep atonia and demonstrate that canine narcolepsy is a useful tool in assessing the pharmacological specificity of antidepressant drugs.
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Dopamine D2 mechanisms in canine narcolepsy
Seiji Nishino,Janis Arrigoni,Delphine Valtier,Joseph D. Miller,Christian Guilleminault,William C. Dement,Emmanuel Mignot +6 more
TL;DR: Using a canine model of the disease, it is found that central D2 antagonists suppressed cataplexy, a form of REM-sleep atonia occurring in narcolepsy, whereas this symptom was aggravated by D2 agonists, suggesting that the effect of D2 compounds on catapLexy is mediated secondarily via the noradrenergic systems.
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Desmethyl Metabolites of Serotonergic Uptake Inhibitors Are More Potent for Suppressing Canine Cataplexy Than Their Parent Compounds
TL;DR: The results suggest that the anticataplectic effect of "selective" serotonergic uptake inhibitors in human narcolepsy might be mediated by their less selective active metabolites.