Jarema Malicki

TL;DR: The results from the first application of such a large-scale genetic screening to vertebrate development of mutagenized zebrafish demonstrate that mutations affecting a variety of developmental processes can be efficiently recovered from zebra fish.

TL;DR: The mutations identified in this screen point to discrete and critical steps in the formation and function of the heart and vasculature.

TL;DR: In a large scale mutagenesis screen for embryonic mutants in zebrafish, this article identified 63 mutations in 24 loci affecting the morphogenesis of the zebra fish brain, which can be broadly classified into two groups, one affecting regionalization along the anterior-posterior or dorsal-ventral axis and the other affecting general features of brain morphology.

TL;DR: In a large scale screen for genetic defects in zebrafish embryogenesis, 49 mutations affecting development of the retina are identified, affecting numerous aspects of eye development, including: specification of the eye anlage, growth rate of the optic cup, establishment of retinal stratification, specification or differentiation ofretinal neurons and formation of the dorsoventral axis in the developing eye.

TL;DR: A large-scale genetic screen for zygotic effect, embryonic lethal mutations in zebrafish reveals three groups of mutations causing distinct effects on cell fates in the gastrula, which provide an approach to understanding the genetic control of gastrulation in vertebrates.