F
Fried J. T. Zwartkruis
Researcher at Utrecht University
Publications - 76
Citations - 12455
Fried J. T. Zwartkruis is an academic researcher from Utrecht University. The author has contributed to research in topics: Rap1 & Guanine nucleotide exchange factor. The author has an hindex of 43, co-authored 73 publications receiving 11787 citations. Previous affiliations of Fried J. T. Zwartkruis include University of Michigan & Harvard University.
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Journal ArticleDOI
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
J. de Rooij,Fried J. T. Zwartkruis,M. H. G. Verheijen,Robbert H. Cool,Sebastian M.B. Nijman,Alfred Wittinghofer,Johannes L. Bos +6 more
TL;DR: The cloned gene encoding a guanine-nucleotide-exchange factor (GEF) for Rap1 is named Epac, which contains a cAMP-binding site and a domain that is homologous to domains of known GEFs for Ras and Rap1 that is regulated directly by cAMP.
Journal ArticleDOI
A genetic screen for mutations affecting embryogenesis in zebrafish
Wolfgang Driever,Lilianna Solnica-Krezel,Alexander F. Schier,Stephan C.F. Neuhauss,Jarema Malicki,Derek L. Stemple,Didier Y.R. Stainier,Fried J. T. Zwartkruis,Salim Abdelilah,Zehava Rangini,J Belak,C Boggs +11 more
TL;DR: The results from the first application of such a large-scale genetic screening to vertebrate development of mutagenized zebrafish demonstrate that mutations affecting a variety of developmental processes can be efficiently recovered from zebra fish.
Journal ArticleDOI
Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2
Attila Garami,Fried J. T. Zwartkruis,Takahiro Nobukuni,Manel Joaquin,Marta Roccio,Hugo Stocker,Sara C. Kozma,Ernst Hafen,Johannes L. Bos,George Thomas +9 more
TL;DR: Evidence is provided that TSC1/2 is a GAP for the small GTPase Rheb and that insulin-mediated RheB activation is PI3K dependent and that Rhe b overexpression induces S6K1 phosphorylation and inhibits PKBosphorylation, as do loss-of-function mutations in TSC 1/2.
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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
Takahiro Nobukuni,Manel Joaquin,Manel Joaquin,Marta Roccio,Stephen G. Dann,So Young Kim,Pawan Gulati,Maya P. Byfield,Jonathan M. Backer,Francois Natt,Johannes L. Bos,Fried J. T. Zwartkruis,George Thomas,George Thomas +13 more
TL;DR: A major pathway by which amino acids control mTOR signaling is distinct from that of insulin and that, instead of signaling through components of the insulin/class 1PI3K pathway, amino acids mediate mTOR activation by signaling through class 3 PI3K, hVps34.
Journal ArticleDOI
Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo.
Didier Y.R. Stainier,Bernadette Fouquet,Jau-Nian Chen,Kerri S. Warren,Brant M. Weinstein,Statten E. Meiler,Manzoor Ali P.K. Mohideen,Stephan C.F. Neuhauss,Liliana Solnica-Krezel,Alexander F. Schier,Fried J. T. Zwartkruis,Derek L. Stemple,Jarema Malicki,Wolfgang Driever,Mark C. Fishman +14 more
TL;DR: The mutations identified in this screen point to discrete and critical steps in the formation and function of the heart and vasculature.