J
Jarkko Magga
Researcher at University of Eastern Finland
Publications - 33
Citations - 1409
Jarkko Magga is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Natriuretic peptide & Brain natriuretic peptide. The author has an hindex of 19, co-authored 33 publications receiving 1372 citations. Previous affiliations of Jarkko Magga include University of Oulu.
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Journal ArticleDOI
Molecular Heterogeneity Has a Major Impact on the Measurement of Circulating N-Terminal Fragments of A- and B-Type Natriuretic Peptides
Minna Ala-Kopsala,Jarkko Magga,Keijo Peuhkurinen,Jaana Leipälä,Heikki Ruskoaho,Juhani Leppäluoto,Olli Vuolteenaho +6 more
TL;DR: Molecular heterogeneity of the circulating forms causes a serious risk of preanalytical errors in assays for NT-proBNP and, to a lesser extent,NT-proANP.
Journal ArticleDOI
Brain natriuretic peptide in plasma, atria, and ventricles of vasopressin- and phenylephrine-infused conscious rats
TL;DR: The present study shows that pressure overload rapidly stimulates BNP gene expression in the hearts of normal and hypertensive rats, and locally generated BNP in the heart muscle may play a significant role in cardiac adaptation to acute changes in mechanical load.
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Adrenomedullin Gene Expression in the Rat Heart is Stimulated by Acute Pressure Overload: Blunted Effect in Experimental Hypertension
Hannu Romppanen,Minna Marttila,Jarkko Magga,Olli Vuolteenaho,P Kinnunen,István Szokodi,Heikki Ruskoaho +6 more
TL;DR: The levels of adrenomedullin (ADM), a newly discovered vasodilating and natriuretic peptide, are elevated in plasma and ventricular myocardium in human congestive heart failure suggesting that cardiac synthesis may contribute to the plasma concentrations of ADM.
Journal Article
B-type natriuretic peptide: a myocyte-specific marker for characterizing load-induced alterations in cardiac gene expression.
TL;DR: BNP can be used as a myocyte-specific marker to identify mechanisms that couple acute mechanical overload to alterations in cardiac gene expression, and the levels of BNP messenger RNA increase substantially in response to cardiac overload.
Journal ArticleDOI
Mechanical load-induced alterations in B-type natriuretic peptide gene expression.
Heikki Tokola,Nina Hautala,Minna Marttila,Jarkko Magga,Sampsa Pikkarainen,Risto Kerkelä,Olli Vuolteenaho,H. Ruskoaho +7 more
TL;DR: Mechanisms that regulate BNP gene expression in cardiac overload, particularly, autocrine-paracrine factors as well as cytoplasmic signaling pathways and transcription factors involved in mechanical stretch-induced B NP gene expression are discussed are discussed.