J
Jaroslav Blahos
Researcher at Charles University in Prague
Publications - 11
Citations - 1064
Jaroslav Blahos is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 9, co-authored 9 publications receiving 1023 citations. Previous affiliations of Jaroslav Blahos include Centre national de la recherche scientifique & Academy of Sciences of the Czech Republic.
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Journal ArticleDOI
Allosteric interactions between GB1 and GB2 subunits are required for optimal GABAB receptor function
Thierry Galvez,Beatrice Duthey,Julie Kniazeff,Jaroslav Blahos,Giorgio Rovelli,Bernhard Bettler,Laurent Prézeau,Jean-Philippe Pin +7 more
TL;DR: The data indicate that multiple allosteric interactions between the two subunits are required for wild‐type functioning of the GABAB receptor and highlight further the importance of the dimerization process in GPCR activation.
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Mapping the Agonist-binding Site of GABAB Type 1 Subunit Sheds Light on the Activation Process of GABABReceptors
Thierry Galvez,Laurent Prézeau,Gérald Milioti,Miloslav Franek,Miloslav Franek,Cécile Joly,Wolfgang Froestl,Bernhard Bettler,Hugues-Olivier Bertrand,Jaroslav Blahos,Jaroslav Blahos,Jean-Philippe Pin +11 more
TL;DR: The data demonstrate the pivotal role played by the GABAB1 subunit in the activation of the heteromeric GABAB receptor and are consistent with the idea that a closed state of the binding domain of family 3 receptors is required for their activation.
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Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition During Hippocampal Maturation in Vitro
Mélanie Sinagra,Danièle Verrier,Daniela Franková,Kimberly M. Korwek,Jaroslav Blahos,Edwin J. Weeber,Olivier J. Manzoni,Pascale Chavis +7 more
TL;DR: It is found that maturation is characterized by the gradual decrease of the participation of NR1/2B receptors to whole-cell NMDAR-mediated currents, which is mirrored by a timely correlated increase of both Reelin immunoreactivity in neuronal somata and the amount of secreted Reelin.
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A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation
Alice Pavlowsky,Antonella Gianfelice,Marta Pallotto,Alice Zanchi,Hugo Vara,Malik Khelfaoui,Malik Khelfaoui,Pamela Valnegri,Xavier Rezai,Silvia Bassani,Dario Brambilla,Jiri Kumpost,Jaroslav Blahos,Michel Roux,Yann Humeau,Jamel Chelly,Jamel Chelly,Maria Passafaro,Maurizio Giustetto,Pierre Billuart,Pierre Billuart,Carlo Sala +21 more
TL;DR: It is shown that IL1RAPL1 is present in dendritic spine where it interacts with PSD-95, a major component of excitatory postsynaptic compartment and regulates the synaptic localization of PSd-95 by controlling c-Jun terminal kinase (JNK) activity and PS D-95 phosphorylation.
Journal ArticleDOI
The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor.
Michaela Havlickova,Laurent Prézeau,Beatrice Duthey,Bernhard Bettler,Jean-Philippe Pin,Jaroslav Blahos +5 more
TL;DR: The i2 loops of GB1 and GB2 in the GABA(B) receptor ability to activate G(alpha)-proteins are investigated and the use of mutations in i2, i3, or both within the GB2 HD brings evidence for the absence of domain swapping enabling the exchange of region including i2 and i3 between the subunits.