C
Carlo Sala
Researcher at University of Milan
Publications - 144
Citations - 12415
Carlo Sala is an academic researcher from University of Milan. The author has contributed to research in topics: Dendritic spine & Postsynaptic density. The author has an hindex of 53, co-authored 130 publications receiving 11114 citations. Previous affiliations of Carlo Sala include National Research Council & University of Milano-Bicocca.
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Journal ArticleDOI
PDZ Domains and the Organization of Supramolecular Complexes
Morgan Sheng,Carlo Sala +1 more
TL;DR: PDZ domains are modular protein interaction domains that bind in a sequence-specific fashion to short C-terminal peptides or internal peptides that fold in a beta-finger.
Journal ArticleDOI
Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin
Scott Naisbitt,Eunjoon Kim,Jian Cheng Tu,Bo Xiao,Carlo Sala,Juli G. Valtschanoff,Richard J. Weinberg,Paul F. Worley,Morgan Sheng +8 more
TL;DR: A novel family of postsynaptic density proteins, termed Shank, that binds via its PDZ domain to the C terminus of PSD-95-associated protein GKAP, and may function as a scaffold protein in the PSD, potentially cross-linking NMDA receptor/PSD- 95 complexes and coupling them to regulators of the actin cytoskeleton.
Journal ArticleDOI
Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer
Carlo Sala,Valentin Piëch,Nathan R. Wilson,Maria Passafaro,Guosong Liu,Morgan Sheng,Morgan Sheng +6 more
TL;DR: Postsynaptic expression of Shank enhances presynaptic function, as measured by increased minifrequency and FM4-64 uptake, suggesting a central role for the Shank scaffold in the structural and functional organization of the dendritic spine and synaptic junction.
Journal ArticleDOI
SynGO : An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
Frank Koopmans,Pim van Nierop,Maria Andres-Alonso,Andrea Byrnes,Tony Cijsouw,Marcelo P. Coba,L. Niels Cornelisse,Ryan J. Farrell,Hana L. Goldschmidt,Daniel P. Howrigan,Natasha K. Hussain,Natasha K. Hussain,Cordelia Imig,Arthur P.H. de Jong,Hwajin Jung,Mahdokht Kohansal-Nodehi,Barbara Kramarz,Noa Lipstein,Ruth C. Lovering,Harold D. MacGillavry,Vittoria Mariano,Vittoria Mariano,Huaiyu Mi,Momchil Ninov,David Osumi-Sutherland,Rainer Pielot,Karl-Heinz Smalla,Haiming Tang,Katherine Tashman,Ruud F. Toonen,Chiara Verpelli,Rita Reig-Viader,Kyoko Watanabe,Jan R.T. van Weering,Tilmann Achsel,Tilmann Achsel,Ghazaleh Ashrafi,Nimra Asi,Tyler C. Brown,Pietro De Camilli,Marc Feuermann,Rebecca E. Foulger,Pascale Gaudet,Anoushka Joglekar,Alexandros K. Kanellopoulos,Alexandros K. Kanellopoulos,Robert C. Malenka,Roger A. Nicoll,Camila Pulido,Jaime de Juan-Sanz,Morgan Sheng,Thomas C. Südhof,Hagen Tilgner,Claudia Bagni,Claudia Bagni,Àlex Bayés,Thomas Biederer,Nils Brose,John Jia En Chua,Daniela C. Dieterich,Eckart D. Gundelfinger,Casper C. Hoogenraad,Richard L. Huganir,Richard L. Huganir,Reinhard Jahn,Pascal S. Kaeser,Eunjoon Kim,Michael R. Kreutz,Peter S. McPherson,Neale Bm,Vincent O'Connor,Danielle Posthuma,Timothy A. Ryan,Carlo Sala,Guoping Feng,Steven E. Hyman,Paul Thomas,August B. Smit,Matthijs Verhage +78 more
TL;DR: It is shown that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes, and among de novo variants associated with neurodevelopmental disorders, including schizophrenia.
Journal ArticleDOI
Dendritic Spines: The Locus of Structural and Functional Plasticity
Carlo Sala,Menahem Segal +1 more
TL;DR: Issues with respect to spine formation and plasticity are addressed and the complexity of molecular pathways involved in regulation of spine structure and function is highlighted, which contributes to the understanding of central synaptic interactions in health and disease.