J
Jason P. Weick
Researcher at University of New Mexico
Publications - 42
Citations - 3626
Jason P. Weick is an academic researcher from University of New Mexico. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 18, co-authored 39 publications receiving 3206 citations. Previous affiliations of Jason P. Weick include Denison University & University of Wisconsin-Madison.
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Journal ArticleDOI
Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
Baoyang Hu,Jason P. Weick,Junying Yu,Li Xiang Ma,Xiaoqing Zhang,James A. Thomson,Su-Chun Zhang +6 more
TL;DR: It is shown that human iPSCs use the same transcriptional network to generate neuroepithelia and functionally appropriate neuronal types over the same developmental time course as hESCs in response to the same set of morphogens; however, they do it with significantly reduced efficiency and increased variability.
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Estradiol activates group I and II metabotropic glutamate receptor signaling, leading to opposing influences on cAMP response element-binding protein.
Marissa I. Boulware,Jason P. Weick,Bryan R. Becklund,Bryan R. Becklund,Sidney P. Kuo,Rachel D. Groth,Paul G. Mermelstein +6 more
TL;DR: Estradiol regulation of CREB is characterized and two putative signaling mechanisms are provided that may account for many of the unexplained observations regarding the influence of estradiol on nervous system function.
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Specification of transplantable astroglial subtypes from human pluripotent stem cells
TL;DR: HPSC-derived neuroepithelia, patterned to rostral-caudal and dorsal-ventral identities with the same morphogens used for neuronal subtype specification, generate immature astrocytes that express distinct homeodomain transcription factors and display phenotypic differences of different astroglial subtypes.
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Functional Neural Development from Human Embryonic Stem Cells: Accelerated Synaptic Activity via Astrocyte Coculture
TL;DR: It is found that differentiating neuronal cells progressively decrease their resting membrane potential, gain characteristic Na+ and K+ currents, and fire mature action potentials by 7 weeks of differentiation, similar to the maturation pattern observed in animals, albeit on a greatly expanded time scale.
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Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits
Yan Liu,Jason P. Weick,Huisheng Liu,Robert Krencik,Xiaoqing Zhang,Lixiang Ma,Lixiang Ma,Guomin Zhou,Melvin Ayala,Su-Chun Zhang +9 more
TL;DR: After transplantation into the hippocampus of mice in which BFCNs and some GABA neurons in the medial septum had been destroyed by mu P75-saporin, human MGE-like progenitor cells, but not ventral spinal progenitors, produced B FCNs that synaptically connected with endogenous neurons, whereas both progenators generated similar populations of GABA neurons.