Jasper Z. Williams

TL;DR: It is shown that synNotch receptors can be used to sculpt custom response programs in primary T cells: they can drive a la carte cytokine secretion profiles, biased T cell differentiation, and local delivery of non-native therapeutic payloads in response to antigen.

TL;DR: A diverse library of multireceptor cell-cell recognition circuits are engineered by using synthetic Notch receptors to transcriptionally interconnect multiple molecular recognition events, which allow engineered T cells to integrate extra- and intracellular antigen recognition, are robust to heterogeneity, and achieve precise recognition by integrating up to three different antigens with positive or negative logic.

TL;DR: Biocompatible immune cell-engaging particles (ICEp) that use synthetic short DNA as scaffolds for efficient and tunable protein loading are developed that can provide new opportunities for immunotherapies.

TL;DR: T cells engineered to recognize and kill tumor cells have emerged as powerful agents for combating cancer, but the ability to engineer T cells remains relatively primitive.

TL;DR: In this article, the instant disclosure of chimeric polypeptides which modulate various cellular processes following a cleavage event induced upon binding of a specific binding member with its binding partner is provided.