Jatinder Vir Singh

TL;DR: Rivastigmine derivatives, tacrine-piperazine hybrid, coumarin-benzofuran derivative, and phenylcinnamide derivative found to be exerting cholinesterase inhibition with IC50 below the range of 1 nM, place them in forefront as potential future drug candidates to further develop potent and specific esterase inhibitors.

TL;DR: In an attempt to develop potent anti-tubulin agents against most dreadful disease cancer, a library of 28 novel triazole tethered isatin-coumarin hybrids were synthesized by click chemistry approach and three most potent hybrids (A-1, A-2 and B-1) were further tested for tubulin polymerization inhibition.

TL;DR: This review summarizes the recent development (2014 and onwards) of these pharmacologically active coumarin hybrids and demonstrates rationale behind their design, structure-activity relationships (SAR) and mechanistic studies performed on these hybrid molecules.

TL;DR: Compounds K-1 and K-2 were found to be the best antimicrobial agents with the minimum inhibitory concentration values of 30 and 312 μg/mL, against Penicillium sp.

TL;DR: Out of various human cancer cell lines employed in sulphorhodamine B (SRB) assay, this lectin was found to have appreciable inhibitory effect on the in vitro proliferation of HCT-15, HOP-62, SW-620, HT-29, IMR-32, SKOV-3, Colo-205, PC-2 and A-549cancer cell lines by 82, 77, 73, 70, 41, 37, 29, 21 and 21%.