Showing papers by "Jaume Reventós published in 2006"
TL;DR: Bone mineral density decreases during the first 24 months of androgen suppression with the most relevant effect occurring in the first year.
92 citations
TL;DR: A small but clinically significant rate of patients under 3-month luteinizing hormone-releasing hormone agonist therapy fail to achieve or maintain castrate testosterone serum levels, which supports the need of monitoring testicular response during LH-RH agonists therapy.
Abstract: Objectives: It was the aim of this study to analyze the failure rates in achieving or maintaining castrate levels of serum testosterone in patients with advanced prostate cancer tre
65 citations
TL;DR: It is hypothesized that p21WAF1/CIP1 and RUNX1/AML1 interact during the initial steps of tumor dissemination in EEC, and mechanisms that could underlie myometrial infiltration and/or the promotion of an invasive phenotype are discussed.
22 citations
TL;DR: Effectively, l-arginine administration in combination with mesh triggered subtle changes in ECM composition that impinged on critical biochemical and structural features and could help to restructure the mechanical load transfer from the implant to the brittle surrounding tissues.
17 citations
TL;DR: The model of experimentally induced canine prostatic hyperplasia provides an adequate setting for the understanding of this disease and the most striking change was the previously unreported finding of caveolae in basal cells.
Abstract: Benign prostatic hyperplasia is a prevalent disease that has received relatively little attention in spite of its morbidity and remarkable social impact. There are few animal models of prostatic hyperplasia. The dog is the only species, along with humans, in which prostatic hyperplasia develops spontaneously and almost universally with age. The aim of the present study has been to compare the ultrastructural findings in a model of experimentally induced canine prostatic hyperplasia with those of the spontaneously developed changes in untreated dogs. An experimental group of 5 male beagle dogs were castrated and treated with combined steroids (3 weekly doses for over 30 weeks). Prostate samples were surgically obtained every 42 days (experimental stages 0 through 6). The control group consisted of 3 noncastrated dogs that were treated with vehicle and in which samples were taken only at stages 0, 1, 4, and 6. Changes in the control groups were similar but of lower intensity compared to those of the experimental groups. In luminal cells, crowding with papillary projections, prominent, branching microvilli, and abundant, often compartmentalized granules were observed. The most striking change was the previously unreported finding of caveolae in basal cells. They were mostly located in the basal aspect of basal cells and were more prominent in the experimental group and in advanced stages of treatment. These ultrastructural findings have not been previously reported in canine or human prostatic hyperplasia and merit further research. The model of experimentally induced canine prostatic hyperplasia provides an adequate setting for the understanding of this disease.
7 citations