Javadi Monisha

TL;DR: Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), which is chemically known as diferuloylmethane, was first isolated exactly two centuries ago in 1815 by two German Scientists, Vogel and Pelletier.

TL;DR: Inclusion of the fruit in one’s diet would assist in a healthy life protected from cancer and also act as an effective chemotherapeutic with no toxic side effects.

TL;DR: Zerumbone has shown its anti-cancer effects by causing significant suppression of proliferation, survival, angiogenesis, invasion, and metastasis through the molecular modulation of different pathways such as NF-κB, Akt, and IL-6/JAK2/STAT3 (interleukin- 6/janus kinase-2/signal transducer and activator of transcription 3) and their downstream target proteins.

TL;DR: A review of the literature available thus far on the expression, function, and role of TIPE proteins in the development and maintenance of various cancers concludes that differential expression of these proteins in normal and cancer tissues and their association with tumor progression and prognosis are significant.

TL;DR: The present study reveals the enormous potential of curcumin, a natural, non-toxic, multi-targeted agent in overcoming drug resistance in cancer cells and sensitizing them to chemotherapeutic drugs.