A survey on deep learning in medical image analysis

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An Introduction To The Event Related Potential Technique

Artificial intelligence (AI) aims to mimic human cognitive functions. It is bringing a paradigm shift to healthcare, powered by increasing availability of healthcare data and rapid progress of analytics techniques. We survey the current status of AI applications in healthcare and discuss its future. AI can be applied to various types of healthcare data (structured and unstructured). Popular AI techniques include machine learning methods for structured data, such as the classical support vector machine and neural network, and the modern deep learning, as well as natural language processing for unstructured data. Major disease areas that use AI tools include cancer, neurology and cardiology. We then review in more details the AI applications in stroke, in the three major areas of early detection and diagnosis, treatment, as well as outcome prediction and prognosis evaluation. We conclude with discussion about pioneer AI systems, such as IBM Watson, and hurdles for real-life deployment of AI.

https://svn.bmj.com/content/svnbmj/2/4/230.full.pdf

Artificial intelligence in healthcare: past, present and future

With a massive influx of multimodality data, the role of data analytics in health informatics has grown rapidly in the last decade. This has also prompted increasing interests in the generation of analytical, data driven models based on machine learning in health informatics. Deep learning, a technique with its foundation in artificial neural networks, is emerging in recent years as a powerful tool for machine learning, promising to reshape the future of artificial intelligence. Rapid improvements in computational power, fast data storage, and parallelization have also contributed to the rapid uptake of the technology in addition to its predictive power and ability to generate automatically optimized high-level features and semantic interpretation from the input data. This article presents a comprehensive up-to-date review of research employing deep learning in health informatics, providing a critical analysis of the relative merit, and potential pitfalls of the technique as well as its future outlook. The paper mainly focuses on key applications of deep learning in the fields of translational bioinformatics, medical imaging, pervasive sensing, medical informatics, and public health.

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Deep Learning for Health Informatics.

What has happened in machine learning lately, and what does it mean for the future of medical image analysis? Machine learning has witnessed a tremendous amount of attention over the last few years. The current boom started around 2009 when so-called deep artificial neural networks began outperforming other established models on a number of important benchmarks. Deep neural networks are now the state-of-the-art machine learning models across a variety of areas, from image analysis to natural language processing, and widely deployed in academia and industry. These developments have a huge potential for medical imaging technology, medical data analysis, medical diagnostics and healthcare in general, slowly being realized. We provide a short overview of recent advances and some associated challenges in machine learning applied to medical image processing and image analysis. As this has become a very broad and fast expanding field we will not survey the entire landscape of applications, but put particular focus on deep learning in MRI. 
Our aim is threefold: (i) give a brief introduction to deep learning with pointers to core references; (ii) indicate how deep learning has been applied to the entire MRI processing chain, from acquisition to image retrieval, from segmentation to disease prediction; (iii) provide a starting point for people interested in experimenting and perhaps contributing to the field of machine learning for medical imaging by pointing out good educational resources, state-of-the-art open-source code, and interesting sources of data and problems related medical imaging.

An overview of deep learning in medical imaging focusing on MRI

This paper provides an overview of recent developments in big data in the context of biomedical and health informatics. It outlines the key characteristics of big data and how medical and health informatics, translational bioinformatics, sensor informatics, and imaging informatics will benefit from an integrated approach of piecing together different aspects of personalized information from a diverse range of data sources, both structured and unstructured, covering genomics, proteomics, metabolomics, as well as imaging, clinical diagnosis, and long-term continuous physiological sensing of an individual. It is expected that recent advances in big data will expand our knowledge for testing new hypotheses about disease management from diagnosis to prevention to personalized treatment. The rise of big data, however, also raises challenges in terms of privacy, security, data ownership, data stewardship, and governance. This paper discusses some of the existing activities and future opportunities related to big data for health, outlining some of the key underlying issues that need to be tackled.

Big Data for Health

Objective: This paper discusses the evolution of pervasive healthcare from its inception for activity recognition using wearable sensors to the future of sensing implant deployment and data processing. Methods: We provide an overview of some of the past milestones and recent developments, categorized into different generations of pervasive sensing applications for health monitoring. This is followed by a review on recent technological advances that have allowed unobtrusive continuous sensing combined with diverse technologies to reshape the clinical workflow for both acute and chronic disease management. We discuss the opportunities of pervasive health monitoring through data linkages with other health informatics systems including the mining of health records, clinical trial databases, multiomics data integration, and social media. Conclusion: Technical advances have supported the evolution of the pervasive health paradigm toward preventative, predictive, personalized, and participatory medicine. Significance: The sensing technologies discussed in this paper and their future evolution will play a key role in realizing the goal of sustainable healthcare systems.

From Wearable Sensors to Smart Implants-–Toward Pervasive and Personalized Healthcare

The contribution of neuroscience to consumer research: A conceptual framework and empirical review

This paper presents a self-adaptive autonomous online learning through a general type-2 fuzzy system (GT2 FS) for the motor imagery (MI) decoding of a brain-machine interface (BMI) and navigation of a bipedal humanoid robot in a real experiment, using electroencephalography (EEG) brain recordings only. GT2 FSs are applied to BMI for the first time in this study. We also account for several constraints commonly associated with BMI in real practice: 1) the maximum number of EEG channels is limited and fixed; 2) no possibility of performing repeated user training sessions; and 3) desirable use of unsupervised and low-complexity feature extraction methods. The novel online learning method presented in this paper consists of a self-adaptive GT2 FS that can autonomously self-adapt both its parameters and structure via creation, fusion, and scaling of the fuzzy system rules in an online BMI experiment with a real robot. The structure identification is based on an online GT2 Gath–Geva algorithm where every MI decoding class can be represented by multiple fuzzy rules (models), which are learnt in a continous (trial-by-trial) non-iterative basis. The effectiveness of the proposed method is demonstrated in a detailed BMI experiment, in which 15 untrained users were able to accurately interface with a humanoid robot, in a single session, using signals from six EEG electrodes only.

/pdf/a-self-adaptive-online-brain-machine-interface-of-a-humanoid-20nifybcjo.pdf

Javier Andreu-Perez

Papers

Deep Learning for Health Informatics.

Big Data for Health

From Wearable Sensors to Smart Implants-–Toward Pervasive and Personalized Healthcare

The contribution of neuroscience to consumer research: A conceptual framework and empirical review

A Self-Adaptive Online Brain–Machine Interface of a Humanoid Robot Through a General Type-2 Fuzzy Inference System