J
Javier Regadera
Researcher at Autonomous University of Madrid
Publications - 106
Citations - 2614
Javier Regadera is an academic researcher from Autonomous University of Madrid. The author has contributed to research in topics: Leydig cell & Sertoli cell. The author has an hindex of 27, co-authored 105 publications receiving 2402 citations. Previous affiliations of Javier Regadera include Complutense University of Madrid & Royal Veterinary College.
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Physiological androgen insensitivity of the fetal, neonatal, and early infantile testis is explained by the ontogeny of the androgen receptor expression in Sertoli cells.
Héctor E. Chemes,Rodolfo Rey,Manuel Nistal,Javier Regadera,Mariana P. Musse,Pilar González-Peramato,Álvaro Serrano +6 more
TL;DR: A lack of androgen receptor expression could explain a physiological Sertoli cell androgen insensitivity during fetal and early postnatal life, which may serve to protect the testis from precocious SERToli cell maturation, resulting in proliferation arrest and spermatogenic development.
Journal ArticleDOI
Androgen receptor distribution in adult human testis.
TL;DR: The distribution of the androgen receptor (AR) in archival human testes was determined immunocytochemically using an affinity-purified peptide-specific rabbit antibody, PG21, and employing a modified biotin-streptavidin-immunoperoxidase method that incorporated a biotin amplification step.
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A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes.
Iñigo Angulo-Barturen,María Belén Jiménez-Díaz,Teresa Mulet,Joaquín Rullas,Esperanza Herreros,Santiago Ferrer,Elena Jimenez,Alfonso Mendoza,Javier Regadera,Philip J. Rosenthal,Ian Bathurst,David L. Pompliano,Federico Gómez de las Heras,Domingo Gargallo-Viola +13 more
TL;DR: Using this model, a reproducible assay of antimalarial activity useful for drug discovery is implemented and validated and demonstrates that P. falciparum contains clones able to grow reproducibly in mice engrafted with human erythrocytes without the use of myeloablative methods.
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Thyroid Hormone Receptor β1 Acts as a Potent Suppressor of Tumor Invasiveness and Metastasis
Olaia Martínez-Iglesias,Susana García-Silva,Stephan P. Tenbaum,Javier Regadera,Fernando Larcher,Jesús M. Paramio,Bjorn Vennström,Ana Aranda +7 more
TL;DR: A novel role for the thyroid hormone receptor as a metastasis suppressor gene is defined, providing a starting point for the development of novel therapeutic strategies for the treatment of human cancer.
Journal Article
Involution of human fetal Leydig cells. An immunohistochemical, ultrastructural and quantitative study.
TL;DR: Quantitative ultrastructural studies revealed that the changes in the number of fetal Leydig cells with age were similar to those found in theNumber of T-positive cells although, for each age studied, absolute values were higher in the ultrastructureural study.