J
Jay Tung
Publications - 18
Citations - 2050
Jay Tung is an academic researcher. The author has contributed to research in topics: Amyloid precursor protein secretase & Dipeptide. The author has an hindex of 7, co-authored 18 publications receiving 2001 citations.
Papers
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Journal ArticleDOI
Purification and cloning of amyloid precursor protein beta-secretase from human brain.
Sukanto Sinha,John P. Anderson,Robin Barbour,Guriqbal S. Basi,Russell J. Caccavello,David Davis,Minhtam Doan,Harry F. Dovey,Normand Frigon,Jin Hong,Kirsten L. Jacobson-Croak,Nancy Jewett,Pamela S. Keim,J. Knops,Ivan Lieberburg,Michael Power,Hua Tan,Gwen Tatsuno,Jay Tung,Dale Schenk,Peter Seubert,Susanna Suomensaari,Shuwen Wang,Donald A. Walker,Jun Zhao,Lisa McConlogue,Varghese John +26 more
TL;DR: A membrane-bound enzyme activity that cleaves full-length APP at the β-secretase cleavage site is described and found to be the predominant β-cleavage activity in human brain, and it is found that human brain β- secretase is a new membrane- bound aspartic proteinase.
Patent
Compounds to treat Alzheimer's disease
TL;DR: The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases as discussed by the authors, and it is shown to be effective in treating dementia.
Patent
Beta-secretase enzyme compositions and methods
John P. Anderson,Guriqbal S. Basi,Minh Tam Doan,Normand Frigon,Varghese John,Michael Power,Sukanto Sinha,Gwen Tatsuno,Jay Tung,Shuwen Wang,Lisa McConlogue +10 more
TL;DR: In this paper, various forms of an active, isolated β-secretase enzyme in purified and recombinant form are disclosed. But none of these forms are useful for use in methods of selecting compounds that modulate βsecretase.
Patent
Statine-derived tetrapeptide inhibitors of beta-secretase
TL;DR: Statine-derived peptide inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal.
Patent
Methods of treatment of amyloidosis using aspartyl-protease inihibitors
Varghese John,Roy K. Hom,Jennifer Sealy,Jose Aquino,Gary Probst,Jay Tung,Larry Fang,Barbara Jagodzinska +7 more
TL;DR: In this paper, the authors describe derivatives of 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating diseases, disorders, and conditions associated with amyloidosis.