D
David Davis
Researcher at Genentech
Publications - 47
Citations - 5039
David Davis is an academic researcher from Genentech. The author has contributed to research in topics: Virus & Antibody. The author has an hindex of 24, co-authored 47 publications receiving 4810 citations. Previous affiliations of David Davis include Institute of Tropical Medicine Antwerp & Royal Free Hospital.
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Journal ArticleDOI
Purification and cloning of amyloid precursor protein beta-secretase from human brain.
Sukanto Sinha,John P. Anderson,Robin Barbour,Guriqbal S. Basi,Russell J. Caccavello,David Davis,Minhtam Doan,Harry F. Dovey,Normand Frigon,Jin Hong,Kirsten L. Jacobson-Croak,Nancy Jewett,Pamela S. Keim,J. Knops,Ivan Lieberburg,Michael Power,Hua Tan,Gwen Tatsuno,Jay Tung,Dale Schenk,Peter Seubert,Susanna Suomensaari,Shuwen Wang,Donald A. Walker,Jun Zhao,Lisa McConlogue,Varghese John +26 more
TL;DR: A membrane-bound enzyme activity that cleaves full-length APP at the β-secretase cleavage site is described and found to be the predominant β-cleavage activity in human brain, and it is found that human brain β- secretase is a new membrane- bound aspartic proteinase.
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Diverse somatic mutation patterns and pathway alterations in human cancers
Zhengyan Kan,Bijay S. Jaiswal,Jeremy Stinson,Vasantharajan Janakiraman,Deepali Bhatt,Howard M. Stern,Peng Yue,Peter M. Haverty,Richard Bourgon,Jianbiao Zheng,Martin Moorhead,Subhra Chaudhuri,Lynn P. Tomsho,Brock A. Peters,Kanan Pujara,Shaun Cordes,David Davis,Victoria Carlton,Wenlin Yuan,Li Li,Weiru Wang,Charles Eigenbrot,Joshua S. Kaminker,David A. Eberhard,Paul Waring,Stephan C. Schuster,Zora Modrusan,Zemin Zhang,David Stokoe,Frederic J. de Sauvage,Malek Faham,Somasekar Seshagiri +31 more
TL;DR: This study provides an overview of the mutational spectra across major human cancers and identifies several potential therapeutic targets.
Journal ArticleDOI
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
Michael Degtyarev,Ann De Mazière,Christine Orr,Jie Lin,Brian Lee,Janet Tien,Wei Wei Prior,Suzanne van Dijk,Hong Wu,Daniel C. Gray,David Davis,Howard M. Stern,Lesley J. Murray,Klaus P. Hoeflich,Judith Klumperman,Lori Friedman,Kui Lin +16 more
TL;DR: It is shown that silencing Akt1 alone, or any combination of Akt isoforms, can suppress the growth of tumors established from phosphatase and tensin homologue–null human cancer cells, and suggests that blocking lysosomal degradation can be detrimental to cancer cell survival when autophagy is activated.
Journal ArticleDOI
Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models
Klaus P. Hoeflich,Daniel C. Gray,Michael Eby,Janet Tien,Leo Wong,Janeko Bower,Alvin Gogineni,Jiping Zha,Mary J. Cole,Howard M. Stern,Lesley J. Murray,David Davis,Somasekar Seshagiri +12 more
TL;DR: Inducible short-hairpin RNA xenograft models are developed to examine the in vivo efficacy of inhibiting oncogenic BRAF and show that tumor regression resulting from BRAF suppression is inducible, reversible, and tightly regulated in these models.
Journal ArticleDOI
Maternal Embryonic Leucine Zipper Kinase/Murine Protein Serine-Threonine Kinase 38 Is a Promising Therapeutic Target for Multiple Cancers
Daniel C. Gray,Adrian M. Jubb,Deborah Hogue,Patrick Dowd,Noelyn M. Kljavin,Sothy Yi,Wei Bai,Gretchen Frantz,Zemin Zhang,Hartmut Koeppen,Frederic J. de Sauvage,David Davis +11 more
TL;DR: Results suggest that Melk may provide a growth advantage for neoplastic cells and, therefore, inactivation may be therapeutically beneficial.