J
Jayaraj Ravindran
Researcher at University of Texas MD Anderson Cancer Center
Publications - 19
Citations - 2195
Jayaraj Ravindran is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Apoptosis & Downregulation and upregulation. The author has an hindex of 14, co-authored 19 publications receiving 2037 citations.
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Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
TL;DR: Curcumin modulates growth of tumor cells through regulation of multiple cell signaling pathways including cell proliferation pathway, cell survival pathway, and protein kinase pathway.
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NF-κB and cancer: how intimate is this relationship
TL;DR: Observations suggest that NF-κB is intimately intertwined with cancer growth and metastasis as well as the mechanism that leads to constitutive activation of NF-β in hematological, gastrointestinal, genitourinary, gynecological, thoracic head and neck, breast, and skin cancers.
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Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake.
Vivek R. Yadav,Sahdeo Prasad,Ramaswamy Kannappan,Jayaraj Ravindran,Madan M. Chaturvedi,Lauri Vaahtera,Jaakko Parkkinen,Bharat B. Aggarwal +7 more
TL;DR: It is demonstrated that CDC had superior attributes compared with free curcumin for cellular uptake and for antiproliferative and anti-inflammatory activities.
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Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.
Jayaraj Ravindran,Hareesh B. Nair,Bokyung Sung,Sahdeo Prasad,Rajeshwar Rao Tekmal,Bharat B. Aggarwal +5 more
TL;DR: The results demonstrate that encapsulation of TQ into nanoparticles enhances its anti-proliferative, anti-inflammatory, and chemosensitizing effects.
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γ-Tocotrienol Inhibits Pancreatic Tumors and Sensitizes Them to Gemcitabine Treatment by Modulating the Inflammatory Microenvironment
Ajaikumar B. Kunnumakkara,Bokyung Sung,Jayaraj Ravindran,Parmeswaran Diagaradjane,Amit Deorukhkar,Sanjit Dey,Cemile Koca,Vivek R. Yadav,Zhimin Tong,Juri G. Gelovani,Sushovan Guha,Sunil Krishnan,Bharat B. Aggarwal +12 more
TL;DR: It is suggested that γ-T3 can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing NF-κB-mediated inflammatory pathways linked to tumorigenesis.