J
Jayasri G. Iyer
Researcher at University of Washington
Publications - 41
Citations - 3411
Jayasri G. Iyer is an academic researcher from University of Washington. The author has contributed to research in topics: Merkel cell carcinoma & Merkel cell polyomavirus. The author has an hindex of 24, co-authored 41 publications receiving 2881 citations. Previous affiliations of Jayasri G. Iyer include University of Washington Medical Center & Medical University of Graz.
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Journal ArticleDOI
Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: Analysis of 5823 cases as the basis of the first consensus staging system
Bianca D. Lemos,Barry E. Storer,Jayasri G. Iyer,Jerri Linn Phillips,Christopher K. Bichakjian,L. Christine Fang,Timothy M. Johnson,Nanette J. Liegeois-Kwon,Clark C. Otley,Kelly G. Paulson,Merrick I. Ross,Siegrid S. Yu,Nathalie C. Zeitouni,David R. Byrd,David R. Byrd,Vernon K. Sondak,Jeffrey E. Gershenwald,Arthur J. Sober,Paul Nghiem,Paul Nghiem,Paul Nghiem +20 more
TL;DR: Although the majority of patients with MCC in this nationwide cohort did not undergo pathologic nodal evaluation, this procedure may be indicated in many cases as it improves prognostic accuracy and has important treatment implications for those found to have microscopic nodal involvement.
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Transcriptome-Wide Studies of Merkel Cell Carcinoma and Validation of Intratumoral CD8+ Lymphocyte Invasion As an Independent Predictor of Survival
Kelly G. Paulson,Jayasri G. Iyer,Andrew Tegeder,Renee Thibodeau,Janell Schelter,Shinichi Koba,David Schrama,William T. Simonson,Bianca D. Lemos,David R. Byrd,David M. Koelle,Denise A. Galloway,J. Helen Leonard,Margaret M. Madeleine,Zsolt B. Argenyi,Mary L. Disis,Juergen C. Becker,Michele A. Cleary,Paul Nghiem +18 more
TL;DR: Intratumoral CD8+ lymphocyte infiltration can be readily assessed on paraffin-embedded tissue, is independently associated with improved MCC-specific survival, and therefore, may provide prognostic information that enhances established MCC staging protocols.
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Association of Merkel Cell Polyomavirus–Specific Antibodies With Merkel Cell Carcinoma
Joseph J. Carter,Kelly G. Paulson,Greg C. Wipf,Danielle Miranda,Margaret M. Madeleine,Lisa G. Johnson,Bianca D. Lemos,Sherry Lee,Ashley H. Warcola,Jayasri G. Iyer,Paul Nghiem,Denise A. Galloway +11 more
TL;DR: Infection with MCPyV is common in the general population, but not other human polyomaviruses, appears to be associated with Merkel cell carcinoma.
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Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients.
Kelly G. Paulson,Joseph J. Carter,Lisa G. Johnson,Kevin W. Cahill,Jayasri G. Iyer,David Schrama,Juergen C. Becker,Margaret M. Madeleine,Paul Nghiem,Denise A. Galloway +9 more
TL;DR: The results suggest that antibodies recognizing T-Ag are relatively specifically associated with MCC, do not effectively protect against disease progression, and may serve as a clinically useful indicator of disease status.
Journal ArticleDOI
Response rates and durability of chemotherapy among 62 patients with metastatic Merkel cell carcinoma
Jayasri G. Iyer,Astrid Blom,Ryan Doumani,C. Lewis,Erica S. Tarabadkar,Austin Anderson,Christine Ma,Amy Bestick,Upendra Parvathaneni,Shailender Bhatia,Paul Nghiem +10 more
TL;DR: First‐line chemotherapy is associated with a high RR in metastatic MCC, but responses are typically not durable, and the median PFS is only 3 months, which suggests rapid emergence of chemoresistance in MCC tumors.